Pregnancy Considerations for Patients with Intracranial Aneurysms - Neurosurgery

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Intracranial aneurysm


I was diagnosed with an intracranial aneurysm and underwent embolization surgery a year ago.
I have been on medication (Clopidogrel) for three months post-surgery, and my doctor informed me that I need to continue the medication for six months.
I would like to inquire if it is safe to become pregnant during this time.
Are there any adverse effects of taking Clopidogrel during pregnancy? Additionally, does pregnancy increase the risk of aneurysm recurrence?

m, 30~39 year old female. Ask Date: 2010/02/28

Dr. Zhang Yuanyi reply Neurosurgery


Hello, according to existing literature, the use of Baoshantong does not increase the risk of embryonic abnormalities.
A 1996 epidemiological study published in the United States found that the risk of aneurysm rupture in pregnant women is 2.5 times that of the general population, particularly after childbirth, where due to changes in blood pressure, the rupture risk is 28 times that of the general population.
Wishing you safety and health, Dr.
Lu Lizheng, Director of the Department of Obstetrics and Gynecology, Taoyuan Hospital, Health Bureau.

Reply Date: 2010/02/28

More Info


When considering pregnancy after undergoing treatment for an intracranial aneurysm, such as endovascular coiling, several important factors must be taken into account. The primary concerns revolve around the effects of medication, the risks associated with pregnancy itself, and the potential for aneurysm recurrence.

Firstly, regarding the medication you are currently taking, which is likely an antiplatelet agent (often referred to as "保栓通" or clopidogrel), it is crucial to understand its implications during pregnancy. Current literature suggests that the use of clopidogrel does not significantly increase the risk of fetal abnormalities. However, the safety of any medication during pregnancy should always be evaluated on a case-by-case basis, and it is essential to have an open dialogue with your healthcare provider about the risks and benefits of continuing this medication while trying to conceive.

The recommendation to continue taking clopidogrel for six months post-surgery is typically aimed at preventing thromboembolic events, which can be particularly concerning after aneurysm treatment. If you are considering pregnancy during this period, it is vital to discuss with your physician whether it is safe to do so while on this medication. They may suggest alternative strategies or adjustments to your treatment plan to ensure both your safety and that of the fetus.

Regarding the risks of pregnancy itself, it is important to note that pregnancy can lead to physiological changes that may affect the vascular system. Studies indicate that the risk of aneurysm rupture can increase during pregnancy, particularly in the later stages and during labor due to elevated blood pressure and increased blood volume. The risk of rupture is reported to be significantly higher postpartum, which is a critical consideration for women with a history of intracranial aneurysms.
In terms of the likelihood of recurrence or complications during pregnancy, while the absolute risk may vary based on individual factors such as the size and location of the aneurysm, as well as your overall health, it is generally advised that women with a history of intracranial aneurysms be closely monitored throughout their pregnancy. Regular follow-ups with both a neurologist and an obstetrician experienced in high-risk pregnancies can help manage any potential complications.

If you are currently three months post-surgery and considering pregnancy, it may be prudent to wait until you have completed the recommended six months of medication, unless your healthcare provider advises otherwise. This waiting period allows for adequate healing and stabilization of your condition, reducing the risk of complications during pregnancy.

In conclusion, while it is possible to have a successful pregnancy after treatment for an intracranial aneurysm, it requires careful planning and coordination with your healthcare team. Ensure that you have thorough discussions with your doctors about your specific situation, the implications of your medication, and the potential risks associated with pregnancy. With appropriate management and monitoring, many women with a history of intracranial aneurysms can have healthy pregnancies and deliveries.

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