Blood Test Results: Insights on Hepatitis B and Liver Health

Blood test report

Hello Doctor, I have a hemangioma in my liver measuring 2.4 cm (it was 1 cm when discovered).
On February 27 of this year, I tested for Hepatitis B, Hepatitis C, and alpha-fetoprotein.
On April 12, I had an abdominal ultrasound, and the doctor did not inform me of any Hepatitis B infection.
On April 15, while donating blood, the blood donation report indicated that the Hepatitis B virus surface antigen (HBsAg) test result was "positive," advising me to refrain from donating blood and recommending further testing at the hospital, including HBsAg, Anti-HBs, and Anti-HBc.
I was advised to have a follow-up blood test in six months.
I received the Hepatitis B vaccine twenty years ago and have antibodies.
Six months ago, all my tests were normal.
Is it possible for the antibodies to disappear and for me to contract Hepatitis B? Is there a possibility of a false positive result? Should I go back to the hospital for retesting? Thank you for your time in answering my questions.

Nanxi, 40~49 year old female. Ask Date: 2010/04/18

Dr. Chen Qifeng reply Gastroenterology and Hepatology

Hello, please visit the hepatobiliary department for further examination.
Any single test may have discrepancies, especially when the concentration values are in the borderline range.
Wishing you health, Dr.
Chen Qi-Feng, Taoyuan Hospital, Department of Health.

Reply Date: 2010/04/18

More Info

Understanding blood test results, particularly concerning Hepatitis B and liver health, can be quite complex. Based on your situation, let's break down the key aspects of your inquiry.

Hepatitis B Testing and Interpretation
1. Understanding HBsAg: The presence of Hepatitis B surface antigen (HBsAg) in your blood indicates an active Hepatitis B virus infection. If your recent blood test showed HBsAg positive, it suggests that you are currently infected with the virus. This is a critical marker for diagnosing Hepatitis B.

2. Antibody Response: After vaccination against Hepatitis B, individuals typically develop antibodies (Anti-HBs) that protect against future infections. However, these antibodies can diminish over time. It is possible, although not common, for someone who was vaccinated to lose their immunity and subsequently become infected with Hepatitis B, especially if they are exposed to the virus.

3. Anti-HBc Testing: The presence of Hepatitis B core antibody (Anti-HBc) can indicate past or current infection. If you have a positive Anti-HBc result alongside a positive HBsAg, it confirms an active infection. If Anti-HBc is positive and HBsAg is negative, it indicates a past infection with possible immunity.

4. False Positives: While it is possible for lab tests to yield false positives, especially in the case of HBsAg, it is relatively uncommon. If there is any doubt about the accuracy of your results, it is advisable to repeat the tests for confirmation.

Liver Health and Vascular Tumors
1. Liver Hemangioma: You mentioned having a 2.4 cm hemangioma in your liver. Hemangiomas are benign vascular tumors and are generally not associated with liver dysfunction or Hepatitis B. However, they should be monitored to ensure they do not grow or cause complications.

2. Impact of Hepatitis B on Liver Health: Chronic Hepatitis B infection can lead to liver inflammation, fibrosis, and potentially cirrhosis or liver cancer over time. Regular monitoring of liver function tests (LFTs) and imaging studies (like ultrasound) is crucial for assessing liver health, especially in the context of Hepatitis B.

3. Liver Function Tests: Your liver function tests (like AST and ALT) provide insight into how well your liver is functioning. Elevated levels can indicate liver inflammation or damage, which can occur with Hepatitis B infection.

Recommendations
1. Follow-Up Testing: Given your positive HBsAg result, it is essential to follow up with your healthcare provider for further testing, including HBsAg, Anti-HBs, and Anti-HBc, to clarify your infection status and determine the best course of action.

2. Regular Monitoring: If you are confirmed to have Hepatitis B, regular monitoring of liver function and imaging studies will be necessary to assess any potential liver damage or complications.

3. Lifestyle Modifications: Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and avoiding alcohol, can help support liver health.
4. Consult a Specialist: It may be beneficial to consult a hepatologist or a specialist in liver diseases for a comprehensive evaluation and management plan tailored to your specific situation.

In conclusion, while your previous vaccination against Hepatitis B provides some level of protection, it is crucial to address the recent positive HBsAg result seriously. Follow-up testing and monitoring will be key in managing your liver health and ensuring any potential issues are addressed promptly.

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