Interactions Between Antidepressants and Gastritis Medications: What You Need to Know

Q: Interactions Between Antidepressants and Gastritis Medications: What You Need to Know

Hello, Le Yang： There are no conflicting interactions between the two categories of medications listed. <br>If taken according to the physician's prescribed timing, there will not be significant drug-drug interactions. <br>However, the first category includes "Qing Li Piao," whic

Antidepressants and medications for the treatment of gastritis?

1.
Currently, I am taking antidepressant medications (long-term use):
1.
Seroquel 75mg three times a day (2 in the morning and 1 in the evening)
2.
Wellbutrin 75mg (1 in the morning)
3.
Zanaflex (light blue, 1 in the evening)
-- All of the above are taken after meals
4.
Lunesta
5.
Melatonin
6.
Clonazepam
-- (1 of each 4, 5, and 6 before bedtime)
2.
Recently, I have been experiencing stomach discomfort.
Another doctor prescribed me medication for gastritis:
1.
Gaviscon (1.5 tablets)
2.
DOMTOO (MOTILIUM)
3.
Magnesium Oxide
4.
Daweison (1, taken 30 minutes before meals)
5.
Quicran (2 before bedtime)
3.
I would like to ask the pharmacist:
1.
Will there be any interactions between these two classes of medications?
2.
Are the aforementioned antidepressant medications metabolized by the liver?

Le Yang, 40~49 year old female. Ask Date: 2010/06/09

Dr. Liu Huiya reply Pharmacology

Hello, Le Yang: There are no conflicting interactions between the two categories of medications listed.
If taken according to the physician's prescribed timing, there will not be significant drug-drug interactions.
However, the first category includes "Qing Li Piao," which is a laxative, and the second category includes "Magnesium Oxide," which is a stool softener.
Both medications have effects on softening stools and relieving constipation, so if you experience loose stools or sudden bowel movements after taking them for a period, you may consider reducing the dosage of one of them.
Among the antidepressants mentioned, "Su Yue" and "Wei Bo Jun" are both metabolized by the liver; only in cases of severe liver cirrhosis would it be necessary to lower the dosage of "Su Yue." The interaction between the two, due to liver metabolism, is not significantly pronounced.
Therefore, at the current dosage you are taking, the impact is minimal.
However, the "You Le Ding" you take before bed may be affected by "Kuei Ke Ding," which could delay the onset of drowsiness to about 30 minutes later (typically, one should feel drowsy 15-20 minutes after taking a sleeping pill).
If this occurs, you might consider taking "Kuei Ke Ding" earlier, either after dinner or after breakfast.
Wishing you peace and safety.

Reply Date: 2010/06/09

More Info

When considering the interactions between antidepressants and medications for gastritis, it is essential to understand the pharmacological profiles of the drugs involved, their metabolic pathways, and potential side effects.

1. Potential Drug Interactions
From the information provided, the antidepressants being taken include Seroquel (Quetiapine), Wellbutrin (Bupropion), and Zoloft (Sertraline), along with other medications like Lunesta (Eszopiclone), Melatonin, and a laxative (ClearLax). The gastritis medications prescribed include Gaviscon, Domperidone (Motilium), Magnesium Oxide, Daweison, and Quicran.

Generally, there are no significant direct interactions between these classes of medications when taken as prescribed. However, there are a few considerations:
- Laxatives and Magnesium Oxide: Both ClearLax and Magnesium Oxide can have a laxative effect. If taken together, they may lead to diarrhea or loose stools. If you experience any gastrointestinal upset, it may be wise to adjust the dosage of one of these medications.

- Quetiapine and Domperidone: Quetiapine is metabolized by the liver, and while Domperidone is not known to significantly affect its metabolism, it is always prudent to monitor for any unusual side effects when combining these medications.

- Sertraline and Quicran: Sertraline is also metabolized in the liver, and while Quicran (an antacid) does not directly interact with it, it may affect the absorption of Sertraline if taken simultaneously. It is advisable to space these medications apart by at least 2 hours to ensure optimal absorption.

2. Metabolism of Antidepressants
The antidepressants listed, particularly Quetiapine and Sertraline, are primarily metabolized in the liver through cytochrome P450 enzymes. In patients with liver impairment, dosage adjustments may be necessary. However, for individuals with normal liver function, the risk of significant drug interactions is relatively low when these medications are taken as directed.

3. Managing Gastritis Symptoms
If you are experiencing gastritis symptoms, it is crucial to follow the prescribed regimen for the gastritis medications. Omeprazole, for instance, is a proton pump inhibitor that reduces stomach acid and can help alleviate symptoms of gastroesophageal reflux disease (GERD) and gastritis. If you notice that your symptoms persist despite treatment, it may be necessary to revisit your healthcare provider for further evaluation or alternative therapies.

4. Recommendations
- Monitor Symptoms: Keep a close eye on your gastrointestinal symptoms. If you notice any worsening or new symptoms, consult your healthcare provider promptly.

- Timing of Medications: To minimize potential interactions, take your antidepressants and gastritis medications at different times of the day. For example, consider taking your gastritis medications 30 minutes before meals and your antidepressants after meals.

- Dietary Considerations: Alongside medication, dietary changes can significantly impact gastritis symptoms. Avoiding spicy foods, caffeine, and alcohol may help reduce irritation in the stomach lining.

- Follow-Up: If symptoms persist or worsen, or if you have concerns about the medications you are taking, do not hesitate to reach out to your healthcare provider for further guidance.

In conclusion, while there are no major interactions between the antidepressants and gastritis medications you are taking, it is essential to monitor your symptoms and adjust the timing of your medications as needed. Always consult with your healthcare provider for personalized advice and treatment adjustments.

Similar Q&A

Understanding Drug Interactions in Psychiatric Medications: A Guide

Hello Dr. Lin, I apologize for the interruption. I was previously taking antidepressant and anti-anxiety medications, but due to recent issues with lymphadenitis, I need to take additional medications (listed below). I would like to ask if there are any potential drug interaction...

Dr. Lin Mianzhang reply Psychiatry
Hello Brisko: The medications you are taking do not have significant interactions with each other. The only thing to be aware of is to complete the full course of antibiotics as prescribed by your physician to prevent the development of antibiotic resistance. Additionally, since ...

Managing GERD: The Impact of Antidepressants and Treatment Options

Hello, Doctor: Since February of this year, I have been experiencing gastroesophageal reflux disease (GERD) and acid reflux. My symptoms include a sensation of excessive stomach acid, resulting in a burning feeling in my stomach, esophagitis, a foreign body sensation in my throat...

Dr. Wang Yaoting reply Psychiatry
Hello: 1. Two medications can be taken together, and it is recommended to pair them with a gastric medication. 2. These medications belong to the benzodiazepine class (abbreviated as BZD), which can be used clinically to treat anxiety and insomnia. They can be taken with PPIs wit...

Managing Depression: Navigating Medication Side Effects and Care

My mother previously contracted Helicobacter pylori and was found to have a cyst in her gallbladder. Perhaps due to excessive worry, she developed depression and consulted a psychiatrist. Initially, her depression was manageable with medication. However, after some time, she bega...

Dr. Su Zongwei reply Psychiatry
Sometimes, it can be difficult to distinguish between physical symptoms of depression and side effects of medication, which requires careful adjustment of the medication. It is important to discuss with your physician whether to discontinue the medication, as stopping abruptly ma...

Understanding Drug Interactions: Safety of Psychiatric and Dermatological Medications

Psychiatry: YOU-JET (Sertraline) 50mg, Eurodin 2mg, Zolpidem*2 (at bedtime) Dermatology: Doxepin 25mg*2, Lyrica 75mg*2 Dermatological pruritus Metabolism: Metformin 500mg, Tamsulosin 0.2mg (to be taken before breakfast) Lansoprazole 30mg, Promethazine 5mg (Gastric protect...

Dr. Lin Mianzhang reply Psychiatry
Hello: The medication Promeran, when used in conjunction with YOU-JET or doxepin, may increase the risk of extrapyramidal symptoms. Extrapyramidal symptoms refer to a group of side effects that involve involuntary movements, including tremors, rigidity, and bradykinesia. However,...