High White Blood Cell Count: Allergies or Other Causes? - Internal Medicine

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What are the causes of elevated white blood cell count?


Dear Doctor, my health check report indicates that my white blood cell count is elevated at approximately 12.7.
Could this be related to my allergic rhinitis? I have had this condition for a long time and often experience nasal congestion and sneezing.
Thank you.

Mr. Li, 20~29 year old female. Ask Date: 2010/06/25

Dr. Xiao Yongxun reply Internal Medicine


Hello: In response to your question.
There are many types of white blood cells in the human body, including neutrophils, basophils, eosinophils, monocytes, and lymphocytes, which can be observed in peripheral blood.
Various diseases can cause changes in the number, size, and morphology of these white blood cells.
An increase in white blood cell count alone can be due to any inflammatory response, medication effects, or even laboratory errors.
If the white blood cell count is particularly high and the morphology of the white blood cells in the peripheral blood smear is notably abnormal, the possibility of hematologic malignancies should be considered.
Allergic rhinitis can theoretically cause changes in white blood cell counts.
Therefore, it is recommended that you discuss your findings with your primary care physician before making any decisions; there is no need to be overly alarmed or anxious.

Reply Date: 2010/06/25

More Info


High white blood cell (WBC) counts, or leukocytosis, can be indicative of various underlying conditions, including infections, inflammation, stress responses, and, in some cases, more serious conditions like leukemia. In your case, with a WBC count of approximately 12.7, it is essential to consider the context of your symptoms and medical history.

Allergic reactions, such as those associated with allergic rhinitis (hay fever), can indeed lead to elevated white blood cell counts, particularly eosinophils, which are a type of white blood cell involved in allergic responses and parasitic infections. When your body encounters allergens, it triggers an immune response that can result in an increase in WBCs as your immune system works to combat the perceived threat. Symptoms of allergic rhinitis, such as nasal congestion, sneezing, and itching, are common and can be quite bothersome.

However, while allergies can contribute to a higher WBC count, it is crucial to rule out other potential causes. For instance, infections (viral or bacterial) are common reasons for elevated WBC counts. Infections can cause your body to produce more white blood cells to fight off pathogens. Additionally, other inflammatory conditions, stress, and even certain medications can lead to leukocytosis.

Given your history of allergic rhinitis, it is plausible that your elevated WBC count could be related to your allergies. However, it is important to consider other factors as well. If you have been experiencing other symptoms, such as fever, fatigue, or unexplained weight loss, these could indicate a more serious condition that warrants further investigation.

To better understand the cause of your elevated WBC count, your healthcare provider may recommend additional tests. These could include:
1. Complete Blood Count (CBC): This test provides a comprehensive overview of your blood cells, including the types and numbers of white blood cells, which can help identify specific patterns indicative of allergies, infections, or other conditions.

2. Differential WBC Count: This test breaks down the different types of white blood cells, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils. An increase in eosinophils, for example, could suggest an allergic reaction or parasitic infection.

3. Allergy Testing: If allergies are suspected as a primary cause, skin or blood tests can help identify specific allergens that may be triggering your symptoms.

4. Further Imaging or Tests: If there are concerns about infections or other underlying conditions, your doctor may recommend imaging studies or additional blood tests.

In conclusion, while your elevated WBC count may be related to your allergic rhinitis, it is essential to consider other potential causes and consult with your healthcare provider for a thorough evaluation. They can help determine the most appropriate next steps based on your symptoms and medical history. If allergies are confirmed as the cause, managing your allergic rhinitis through avoidance of triggers and appropriate medications can help alleviate your symptoms and potentially normalize your WBC count.

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