G6PD Deficiency and Hepatitis B Vaccination: Your Questions Answered

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Hello Doctor: I have G6PD deficiency, but it seems my father does not have it.
Previously, my mother had a blood test, and it was found that she also does not have G6PD deficiency.
I later went to a family medicine clinic for further examination, and after blood tests and reports, the doctor indicated that my hemoglobin levels are very high, with no signs of anemia.
Since my mother does not have G6PD deficiency, the doctor mentioned that the probability of me having it is essentially zero, so I am wondering if I should be considered free of G6PD deficiency.

Regarding the hepatitis B vaccine, during a previous visit to a hepatobiliary specialist, I was found to have no antibodies (not infected), but the doctor mentioned that it could be due to low concentration and that white blood cells usually have memory, so there was no need for re-vaccination.
However, when I visited the family medicine clinic, the doctor reviewed my previous tests from the hepatobiliary specialist and suggested that I should get vaccinated again.
Now, I am unsure whether I should receive the vaccine or not.
Additionally, if I do decide to get vaccinated, is there anything I need to pay attention to? Typically, how much does the hepatitis B vaccine cost out-of-pocket? Thank you! ^^

Lai, 10~19 year old female. Ask Date: 2010/07/08

Dr. Liao Yaopan reply Family Medicine

1.
The test for G6PD deficiency measures the level of the enzyme "G6PD," which is different from hemoglobin.
Additionally, this condition is X-linked recessive, meaning that the mother can be an asymptomatic carrier of the gene.

2.
The hepatitis B vaccine is administered when both the surface antigen and surface antibody are negative.
Please confirm this with your physician for evaluation.
The cost for one dose is approximately over three hundred NT dollars.
Thank you.

Reply Date: 2010/07/08

More Info

Understanding G6PD Deficiency and Hepatitis B Vaccination
Thank you for your questions regarding G6PD deficiency and Hepatitis B vaccination. It’s great that you are taking a proactive approach to your health. Let’s break down your concerns into two main areas: G6PD deficiency and the Hepatitis B vaccination.

G6PD Deficiency
G6PD deficiency, also known as favism, is a genetic condition that affects the enzyme glucose-6-phosphate dehydrogenase. This enzyme plays a crucial role in protecting red blood cells from damage. Individuals with G6PD deficiency may experience hemolytic anemia when exposed to certain triggers, such as certain medications, infections, or foods like fava beans.

From your description, it seems that both your mother and father do not have G6PD deficiency, which significantly reduces the likelihood of you having it as well. G6PD deficiency is inherited in an X-linked recessive pattern, meaning that it is typically passed down from carrier mothers to affected sons. Since your mother has been tested and found negative for the condition, the probability of you having G6PD deficiency is indeed very low. However, if you have concerns or symptoms that suggest G6PD deficiency, it may be worth discussing further testing with your healthcare provider.

Hepatitis B Vaccination
Regarding the Hepatitis B vaccination, it is essential to understand your current immune status. You mentioned that you were previously tested and found to have no detectable antibodies against Hepatitis B, which could indicate that you are not immune. However, it is also possible that your antibody levels are low enough that they were not detected in the test, but your immune system still has a memory of the virus.

The recommendation to receive the Hepatitis B vaccine again can depend on several factors, including your risk of exposure to the virus and your healthcare provider's assessment of your immune status. If you are at risk of exposure (for example, if you work in a healthcare setting or have close contact with someone who is Hepatitis B positive), it may be prudent to receive the vaccine.

Vaccination Considerations
If you decide to proceed with the vaccination, here are some considerations:
1. Timing: The Hepatitis B vaccine is typically administered in a series of three doses. The second dose is given one month after the first, and the third dose is given six months after the first dose.

2. Monitoring: After vaccination, it is advisable to have your antibody levels checked about one to two months after completing the series to ensure that you have developed adequate immunity.

3. Cost: The cost of the Hepatitis B vaccine can vary depending on your location and whether you are receiving it through a public health program or a private provider. On average, the cost for the vaccine can range from $30 to $150 per dose, but many insurance plans cover the vaccination.

4. Side Effects: Common side effects of the Hepatitis B vaccine include soreness at the injection site, mild fever, and fatigue. Serious side effects are rare.

5. Consultation: It is always best to consult with your healthcare provider regarding your vaccination status and any potential need for revaccination, especially considering your health history and any other underlying conditions.

In conclusion, while your risk of having G6PD deficiency appears low, it is essential to stay informed and consult with your healthcare provider for any further testing if needed. Regarding the Hepatitis B vaccination, if there is any uncertainty about your immune status, discussing the possibility of revaccination with your healthcare provider is a wise choice. They can provide personalized advice based on your health history and risk factors.

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