Low-dose aspirin and habitual miscarriage?
Dr.
Chang, thank you for your response regarding my concerns.
My previous four miscarriages occurred around 6 to 8 weeks.
What is the minimum low dose of aspirin that can help prevent recurrent miscarriage? How long should it be taken after conception? Will low-dose aspirin have any effects on the fetus? Thank you for your patience.
ciccia, 20~29 year old female. Ask Date: 2010/07/19
Dr. Zhang Kunmin reply Obstetrics and Gynecology
Hello: It is generally recommended to take 100 mg/day of aspirin to prevent recurrent miscarriage, starting after pregnancy is confirmed and continuing until around 36 weeks.
The causes of recurrent miscarriage are numerous, but chromosomal abnormalities in parents account for less than 3% of cases.
Most miscarriages are of unknown origin, with a significant number of women experiencing uterine blood flow obstruction, preventing the embryo from receiving sufficient nutrients for development.
Since aspirin has anticoagulant properties, it can improve blood flow, effectively addressing the issue of nutrient deficiency for the embryo.
In the past, the medical community in Taiwan used steroids to treat recurrent miscarriage, but this often led to maternal obesity and osteoporosis, making it less commonly used today.
Currently, obstetricians and gynecologists often use a type of anticoagulant that is expensive and requires daily injections, which is less convenient compared to aspirin.
In Europe and the United States, aspirin has been used for years to treat recurrent miscarriage; however, the dosage and duration for women should follow a doctor's instructions.
Aspirin is not suitable for women who are allergic to it, those preparing for surgery, or patients with hemophilia.
This information is provided for your reference.
Thank you! Dr.
Zhang
Reply Date: 2010/07/19
More Info
Low-dose aspirin has been studied for its potential role in preventing recurrent miscarriages, particularly in women with certain risk factors. The typical dosage considered "low-dose" is usually around 81 mg (commonly referred to as "baby aspirin") taken once daily. This dosage is generally well-tolerated and is thought to help improve blood flow to the placenta, reduce inflammation, and prevent clotting disorders that may contribute to pregnancy loss.
In terms of duration, it is often recommended that women continue taking low-dose aspirin from the time of conception until the end of the first trimester, which is around 12 weeks of gestation. However, some healthcare providers may suggest continuing the medication into the second trimester, especially if there are ongoing concerns about placental function or if the woman has a history of conditions such as antiphospholipid syndrome, which is associated with recurrent pregnancy loss.
Regarding the safety of low-dose aspirin during pregnancy, research indicates that it is generally considered safe for use in pregnant women when prescribed by a healthcare provider. The benefits of preventing miscarriage or other complications often outweigh the risks. However, it is crucial to consult with your healthcare provider before starting any medication during pregnancy, as individual circumstances can vary significantly.
It is also important to note that while low-dose aspirin can be beneficial for some women, it is not a universal solution for all cases of recurrent miscarriage. The underlying causes of miscarriage can be multifactorial, including genetic factors, anatomical issues, hormonal imbalances, and autoimmune disorders. Therefore, a thorough evaluation by a healthcare professional is essential to determine the most appropriate treatment plan tailored to your specific situation.
In summary, low-dose aspirin (81 mg daily) is commonly recommended for women with a history of recurrent miscarriages, particularly those with specific risk factors. It is typically taken from conception until the end of the first trimester, but the duration may vary based on individual circumstances. Always consult with your healthcare provider to ensure the best approach for your health and the health of your future pregnancy.
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