Managing Elevated Liver Enzymes: Key Questions and Insights for Caregivers - Gastroenterology and Hepatology

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Regarding issues related to elevated liver enzymes?


Hello, Doctor.
I would like to ask a question regarding my mother, who has had abnormal liver function for over 10 years and has been regularly monitored through blood tests.
This year's health check results showed: AST: 65, ALT: 111.
She does not have hepatitis B or C, but she has moderate fatty liver and is classified as middle-aged and obese.

1.
Given her ongoing abnormal liver function, does she need medication, or is regular monitoring sufficient?
2.
Is her liver function abnormal solely due to fatty liver, or could there be other health warnings? (Currently, my mother only takes care of her grandchildren and does not have any work-related stress, so fatigue should not be an issue.)
3.
There are advertised chicken essence products on the market that claim to lower liver enzymes.
Would these be beneficial for her?
Thank you for your valuable advice and guidance.

Xiao Jia, 30~39 year old female. Ask Date: 2010/08/10

Dr. Chen Shidian reply Gastroenterology and Hepatology


Hello, Miss: There is no specific medication for fatty liver.
A GPT level of 80 can use liver-protective medications covered by health insurance, but the effects are not significant.
Weight loss is the most important factor, along with monitoring changes in GPT levels.
Patients are at risk for diabetes, so please be cautious.
Additionally, it is necessary to wait for the specialist to rule out other liver disease factors.
Changhua Hospital cares about your health.
Chen Shidian.

Reply Date: 2010/08/10

More Info


Managing elevated liver enzymes, particularly in the context of chronic liver conditions such as fatty liver disease, requires a nuanced understanding of the underlying causes and appropriate management strategies. Here are some insights based on your questions regarding your mother's liver health.

1. Medication vs. Monitoring: In cases where liver enzymes are elevated but there is no evidence of viral hepatitis (such as Hepatitis B or C), and the primary diagnosis is non-alcoholic fatty liver disease (NAFLD), the approach often involves lifestyle modifications rather than immediate pharmacological intervention. Regular monitoring of liver function tests (LFTs) is essential to track any changes over time. If the liver enzymes remain consistently elevated or worsen, further investigation may be warranted, including imaging studies or a liver biopsy to assess for potential fibrosis or cirrhosis. In the absence of significant liver damage, lifestyle changes such as weight loss, dietary modifications, and increased physical activity can significantly improve liver function.

2. Causes of Liver Dysfunction: While moderate fatty liver is a common cause of elevated liver enzymes, it is crucial to rule out other potential factors. These can include metabolic syndrome, diabetes, hyperlipidemia, and even certain medications or supplements that may affect liver function. Given that your mother is classified as middle-aged and obese, her fatty liver could be a manifestation of metabolic syndrome, which is often associated with insulin resistance. It is advisable to have her evaluated for other metabolic risk factors, including blood sugar levels and lipid profiles, to ensure a comprehensive understanding of her health status.

3. Effectiveness of Supplements: The market is flooded with products claiming to lower liver enzyme levels, including chicken essence and various herbal supplements. However, the efficacy of these products is often not supported by robust clinical evidence. While some ingredients may have hepatoprotective properties, relying solely on these supplements without addressing the root causes of liver dysfunction—such as obesity and dietary habits—may not yield significant benefits. It is essential to approach such products with caution and consult with a healthcare provider before introducing them into her regimen.

In summary, your mother's elevated liver enzymes, primarily attributed to moderate fatty liver, should be managed through lifestyle interventions rather than immediate medication. Regular follow-ups are crucial to monitor her liver function and assess for any progression of liver disease. Additionally, a thorough evaluation for other metabolic conditions is recommended to ensure comprehensive care. Always consult with a healthcare professional before starting any new supplements or treatments to ensure they align with her overall health strategy.

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