Lipomas: Causes, Treatment Options, and Concerns About Malignancy - Oncology

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Lipomas and fibromas continue to grow; what should I do? Why? Why?


Hello, I have been experiencing lipomas since I was about 18 years old, and I currently have accumulated around 30 of them throughout my body (mostly distributed in the abdomen, waist, hips, thighs, upper arms, and back, varying in size and shape, some soft and some firm).
Most of them have developed in the past five years, and some are still growing, occasionally causing pain.
About five years ago, I underwent surgery to remove two of them, which were confirmed as benign through biopsy, but new tumors have continued to appear and grow over the years.
Therefore, I am very concerned about the possibility of them turning into malignant tumors.
Over the past few years, I have also consulted at teaching hospitals such as Veterans General Hospital, but the conclusions I received were mostly: 90% are benign, and they can be removed or left alone.
When I inquired about the cause, they said it is unknown or attributed to my constitution.
I would like to understand: 1.
What is the actual cause? Why do they keep growing? 2.
Besides surgical removal (how can I remove over 30 of them?), what are the effective solutions? 3.
Are there methods to inhibit the formation of new lipomas? 4.
Is there a risk of them turning into malignant tumors? I would greatly appreciate your answers.
Thank you!

min, 30~39 year old female. Ask Date: 2002/02/01

Dr. Fan Sheng reply Oncology


Luckmin: The possible causes of multiple lipomas include chronic alcohol addiction and genetic mutations.
Recently, the most studied mutated gene has been HMGA (High Mobility Group A Protein).
Currently, there is no effective treatment targeting the mutated gene.
Generally, surgical excision and liposuction remain the primary treatment methods for multiple lipomas.
This condition is not expected to transform into a malignant tumor.
I will share any new information with you as soon as I have it.
Thank you for your inquiry.

Reply Date: 2002/02/01

More Info


Understanding lipomas can be a source of concern for many individuals, especially when they notice multiple growths on their body. Lipomas are benign tumors composed of adipose (fat) tissue and are generally considered harmless. However, your experience of having over 30 lipomas, some of which are painful and continue to grow, raises valid questions about their causes, treatment options, and the potential for malignancy.


1. Causes of Lipomas
The exact cause of lipomas remains largely unknown, but several factors may contribute to their development:
- Genetics: There is a hereditary component to lipomas. If you have a family history of lipomas, you may be more likely to develop them yourself.

- Age: Lipomas are more commonly found in middle-aged adults, although they can occur at any age.

- Obesity: While not directly causing lipomas, being overweight may increase the likelihood of developing them.

- Trauma: Some studies suggest that trauma to an area may trigger the formation of a lipoma, although this is not universally accepted.

The reason why you may be experiencing a rapid increase in the number of lipomas could be related to your genetic predisposition or other unidentified factors that affect your body’s fat tissue.


2. Treatment Options
The primary treatment for lipomas is surgical removal, especially if they are causing discomfort or pain. However, as you mentioned, having over 30 lipomas makes surgical intervention challenging. Here are some options to consider:
- Surgical Excision: This is the most definitive treatment. If a lipoma is painful or growing, it is often recommended to remove it. However, removing all lipomas may not be feasible due to their number.

- Liposuction: This technique can be used for larger lipomas, where the fatty tissue is suctioned out. However, this method may not remove the entire lipoma, leading to a chance of recurrence.

- Observation: If the lipomas are asymptomatic and not growing, a "watch and wait" approach may be appropriate. Regular monitoring can help you keep track of any changes.


3. Preventing New Lipomas
Currently, there are no proven methods to prevent the formation of new lipomas. Maintaining a healthy lifestyle, including a balanced diet and regular exercise, may help manage your overall health but is unlikely to stop the development of lipomas. If you have a genetic predisposition, it may be challenging to prevent their occurrence entirely.


4. Concerns About Malignancy
The concern about lipomas turning malignant is understandable. However, lipomas are typically benign and do not transform into cancer. The risk of a lipoma becoming malignant is extremely low. That said, there are rare cases of liposarcoma, a malignant tumor of adipose tissue, which can be mistaken for a lipoma. If you notice any changes in size, shape, or if the lipoma becomes painful, it is essential to consult with a healthcare provider for further evaluation.


Conclusion
In summary, while lipomas are generally benign and not a cause for alarm, your situation warrants close monitoring and possibly further evaluation by a specialist. If you have concerns about the growth of new lipomas or changes in existing ones, it may be beneficial to consult with a dermatologist or a surgeon who specializes in soft tissue tumors. They can provide personalized advice and discuss the best management strategies for your specific case. Remember, maintaining open communication with your healthcare provider is key to addressing your concerns and ensuring your well-being.

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