Persistent Headaches: When Pain Medications Fail to Provide Relief - Neurology

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If taking medication for headaches does not improve the symptoms, it is important to consult a healthcare professional for further evaluation and management?


Hello Doctor: I have been experiencing persistent headaches lately.
The pain subsides when I sleep, but as soon as I wake up, the headache returns.
This has been going on for a week now.
During this time, I visited a clinic and also consulted with a family medicine doctor at a hospital.
However, the physician only assessed my condition based on my description and concluded that I am experiencing migraines.
They prescribed me a variety of pain medications, but honestly, the medication has not improved my headache condition at all.
I still wake up every morning with a headache, and the only relief I find is when I take a nap during the day.
I would like to ask the doctor what kind of tests I should undergo or if there are any recommendations to help with my headache issues.
The pain is a constant throbbing sensation that lasts all day, making me feel uncomfortable and nauseous.
I often feel my heart racing, and I'm unsure if this is related to my discomfort.

Here are the pain medications I am currently taking:
- Propra tablets 10mg (Propranolol Inderal 10mg) for anxiety-induced tachycardia and migraines.
- Anrokiw tablets (Chlorzoxazone Solaxin 200mg) for muscle tension, joint pain, lower back pain, and back pain.
- Cafegotawiwe s.c.
tablets for migraines and headaches.
- Werew ewteric-wicroewcapsulate voren 50mg (non-steroidal anti-inflammatory drug).
- Ibu1-400 degiton f.c.
for chronic rheumatoid arthritis, joint pain, and neuralgia.
- Sol1-250 tonipin for lower back pain, joint pain, muscle pain, limb pain, facial nerve spasms, and neuralgia.
- Val21-2 Diazepam for anxiety, insomnia, and sedation.
- Str-5mg Magocain for relief from discomfort or burning sensation, excessive stomach acid, and indigestion.
I apologize for the trouble, Doctor.
Thank you.

Yifan, 30~39 year old female. Ask Date: 2012/01/22

Dr. Gao Chunde reply Neurology


In general, if a typical migraine improves after taking the medications you mentioned, it should be nearly resolved.
If there is no improvement, one possibility is that it is a status migrainosus, which requires stronger injectable medications for ongoing treatment.
Another consideration is to reassess for issues beyond migraines, allowing the physician to examine in detail for any accompanying symptoms such as fever, neck stiffness, or neurological deficits associated with the headache, in order to further determine the underlying cause.

Reply Date: 2012/01/22

More Info


Persistent headaches can be a challenging and frustrating condition, especially when standard pain medications fail to provide relief. Based on your description, it appears that you have been experiencing headaches consistently for a week, with symptoms that worsen upon waking. You have also mentioned that the pain is severe enough to cause nausea and an increased heart rate, which can be distressing.

From a medical standpoint, there are several potential causes for your persistent headaches. While your healthcare providers have suggested that you may be experiencing migraines, it is essential to consider other possibilities as well. Here are some key points to consider:
1. Types of Headaches: Headaches can be classified into primary and secondary types. Primary headaches include migraines, tension-type headaches, and cluster headaches. Secondary headaches are caused by underlying conditions such as sinus infections, high blood pressure, or even more serious issues like tumors or aneurysms. Given the severity and persistence of your symptoms, it may be prudent to explore the possibility of secondary headaches.

2. Diagnostic Evaluation: Since your symptoms have not improved with medication, it may be time to undergo further diagnostic testing. A thorough evaluation by a neurologist is recommended. This may include imaging studies such as a CT scan or MRI of the brain to rule out any structural abnormalities. Blood tests may also be necessary to check for signs of infection or inflammation.

3. Medication Review: You mentioned taking multiple medications, including propranolol (Inderal), which is often used for migraine prevention and to manage anxiety-related symptoms. However, if your headaches are not responding to these medications, it may be worth discussing alternative treatment options with your doctor. Some patients benefit from preventive medications specifically tailored for migraines, such as triptans or newer classes of medications like CGRP inhibitors.

4. Lifestyle Factors: Consider evaluating your lifestyle for potential triggers. Factors such as stress, sleep patterns, hydration, and diet can significantly impact headache frequency and severity. Maintaining a regular sleep schedule, staying hydrated, and managing stress through relaxation techniques or therapy may help alleviate your symptoms.

5. Non-Pharmacological Approaches: In addition to medication, non-pharmacological treatments can be beneficial. Techniques such as cognitive-behavioral therapy (CBT), biofeedback, acupuncture, and physical therapy may provide relief for some individuals. These approaches can help address the underlying stress and tension that may contribute to your headaches.

6. Follow-Up Care: Since your symptoms have persisted despite treatment, it is crucial to maintain open communication with your healthcare providers. Regular follow-up appointments will allow for ongoing assessment of your condition and adjustments to your treatment plan as needed.

In summary, persistent headaches that do not respond to medication warrant further investigation. A comprehensive evaluation by a neurologist, along with lifestyle modifications and consideration of alternative treatments, may provide the relief you seek. It is essential to advocate for your health and ensure that all potential causes are thoroughly explored. Please consult with your healthcare provider to discuss these options and develop a tailored plan for your situation.

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