Brain Connectivity Changes in Mental Health - Psychiatry

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Cerebral neural connectivity issues?


Could you please tell me if the changes described by Ms.
Hong Lan in her work "Change is the Nature of the Brain" indicate that neural connections in the brain can change in the moment? How long does it take to eliminate existing neural connections in the brain? Thank you.

I'm sorry, 30~39 year old female. Ask Date: 2012/02/07

Dr. Lin Junyuan reply Psychiatry


Hello, the central nervous system, like other systems in the body, can be damaged or age, but it also has the potential for repair.
However, regarding the mention of "removing" "existing neural connections in the brain," to my knowledge, there are no human trial reports due to ethical considerations.
There are neurotransmitters, neurons, and synapses within the brain that can change through medications, learning, and behavioral therapies.
As for how long these changes take, there is currently no unified answer.
For example, with antipsychotic medications, it may take 4 to 8 weeks.
I hope this information is helpful to you.

Reply Date: 2012/02/07

More Info


Understanding brain connectivity changes in mental health is a complex and evolving field. The brain is a highly dynamic organ, and its neural connections can indeed change over time due to various factors, including experiences, learning, and even mental health conditions. This phenomenon is often referred to as "neuroplasticity," which is the brain's ability to reorganize itself by forming new neural connections throughout life.
When discussing the insights of Ms. Hong Lan regarding the nature of brain changes, it's essential to recognize that the brain's connectivity can be altered both in the short term and long term. For instance, engaging in new learning experiences or therapeutic interventions can lead to immediate changes in neural pathways. However, the process of significantly altering or "removing" old neural connections is more complex and typically requires sustained effort over time.

The time it takes to modify existing neural connections can vary widely depending on several factors, including the individual’s age, the nature of the changes being pursued, and the methods employed (such as cognitive-behavioral therapy, medication, or lifestyle changes). For example, research indicates that certain types of cognitive-behavioral therapy can lead to observable changes in brain activity and connectivity within a matter of weeks. However, more profound changes, such as those associated with recovery from severe mental health conditions, may take months or even years of consistent effort and treatment.

It's also important to note that while we can influence the brain's connectivity, we cannot simply "remove" old connections. Instead, we can create new pathways that may overshadow or compensate for the old ones. This is akin to rerouting a road rather than demolishing it entirely. For instance, in the context of depression, therapeutic interventions can help individuals develop healthier thought patterns and coping mechanisms, which can lead to a reorganization of brain connectivity associated with mood regulation.

In terms of the duration required to see changes in neural connectivity, it is not a one-size-fits-all answer. For example, if someone is undergoing treatment for depression with medication, it may take several weeks to months to notice significant improvements in mood and cognitive function. Similarly, engaging in regular physical activity, mindfulness practices, or cognitive training can also yield benefits over time, but the timeline can vary based on individual circumstances.

In summary, the brain's neural connections are indeed subject to change, and while some alterations can occur rapidly, others require sustained effort and time. The journey of modifying brain connectivity, especially in the context of mental health, is a gradual process that involves patience, commitment, and often professional guidance. Understanding this dynamic nature of the brain can empower individuals to engage in practices that promote mental well-being and cognitive resilience.

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