Can You Safely Use Progesterone (Aistie) Beyond Three Months? - Obstetrics and Gynecology

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Progesterone (Estradiol)


Hello Doctor: Last time you mentioned that progesterone can be taken long-term.
I would like to know how long that is.
I am currently over 13 weeks pregnant.
I haven't taken progesterone for a while since there was no bleeding, but I went out more recently.
This morning, I noticed pink discharge.
Today, I took two of the small white pills you prescribed, which are Estradiol.
Can I continue taking it after three months?

Xiao Mi Feng, 30~39 year old female. Ask Date: 2012/05/21

Dr. Liu Yuhong reply Obstetrics and Gynecology


Progesterone can be used for: 1.
Treating threatened miscarriage before 20 weeks (standard use), and 2.
Preventing recurrent preterm birth in mothers with a history of preterm delivery between 20 to 34 weeks (experimental therapy).
In summary, progesterone can be used up to 34 weeks for the treatment of threatened miscarriage or prevention of recurrent preterm birth.
Progesterone capsules should be stored in a cool, dry place and typically remain stable for three months.

Reply Date: 2012/05/21

More Info


When considering the long-term use of progesterone, such as Aistie (which contains progesterone), it is essential to understand both the benefits and potential risks associated with extended use. Progesterone is often prescribed for various reasons, including hormone replacement therapy, management of menstrual disorders, and support during pregnancy, particularly in cases of luteal phase deficiency or recurrent pregnancy loss.


Long-term Use of Progesterone
1. Duration of Use: While progesterone can be used for extended periods, the specific duration should be determined by your healthcare provider based on your individual health needs and circumstances. In many cases, progesterone can be safely used for several months or even longer, especially in the context of pregnancy support. However, continuous monitoring and evaluation by a healthcare professional are crucial.

2. Monitoring for Side Effects: Long-term use of progesterone may lead to side effects, including mood changes, weight gain, breast tenderness, and potential impacts on liver function. Regular follow-ups with your healthcare provider can help manage these side effects and assess the necessity of continuing treatment.

3. Pregnancy Considerations: If you are currently pregnant and have been prescribed progesterone, it is often continued until the placenta is sufficiently developed to produce adequate hormones on its own, typically around the 10-12 week mark. However, some women may require continued progesterone support throughout their pregnancy, especially if they have a history of pregnancy complications.

4. Signs to Watch For: The presence of pink discharge or spotting, as you mentioned, can be concerning, especially if it is a new symptom. While some light spotting can be normal in early pregnancy, it is essential to report any changes to your healthcare provider immediately. They may want to evaluate your progesterone levels and overall pregnancy status to ensure everything is progressing normally.


Recommendations
- Consult Your Doctor: Since you are currently experiencing pink discharge, it is crucial to contact your healthcare provider as soon as possible. They may want to perform an ultrasound or check hormone levels to ensure that everything is okay with your pregnancy.

- Discuss Long-term Use: During your consultation, discuss the possibility of continuing progesterone beyond three months. Your doctor can provide personalized advice based on your health history and current pregnancy status.

- Consider Alternatives: If there are concerns about the long-term use of progesterone, your healthcare provider may discuss alternative treatments or adjustments to your current regimen.

Conclusion
In summary, while progesterone can be used safely for extended periods, especially in the context of pregnancy, it is essential to have ongoing communication with your healthcare provider. They can help monitor your health, manage any side effects, and ensure that your treatment plan is appropriate for your specific situation. If you experience any unusual symptoms, such as spotting or changes in discharge, do not hesitate to seek medical advice promptly. Your health and the health of your pregnancy are of utmost importance, and your healthcare provider is your best resource for navigating these concerns.

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