Elevated SGPT Levels and Hepatitis B Antibody Testing

Q: Elevated SGPT Levels and Hepatitis B Antibody Testing

Hello： The antibodies produced by the hepatitis B vaccine are not permanently effective. <br>Research indicates that some individuals who received the hepatitis B vaccine at birth may not have detectable hepatitis B antibodies by adolescence and may even lose immune memory. <br>I

Liver dysfunction

Hello, Doctor:
1.
Regarding my serum glutamate-pyruvate transaminase (SGPT) level, which is 57 (reference range 0-55), if it is only slightly above the normal range by 2, is it likely that this is just a minor elevation in liver enzymes?
2.
I have already visited the outpatient clinic today and had blood tests done (including tests for hepatitis B and C).
I will also undergo an abdominal ultrasound.
Additionally, I would like to ask about my fifth-grade blood test, which showed no hepatitis B antibodies, but the doctor at that time advised that a booster was not necessary.
Last year, when I visited the family medicine department, the physician recommended that I receive a booster shot, stating that if I still had no antibodies, I would not need to continue with boosters.
It seems that my current blood test will also check for antibodies.
If I have no antibodies, is there a need for a booster shot? Thank you!

Lai, 20~29 year old female. Ask Date: 2012/07/21

Dr. Cai Anshun reply Gastroenterology and Hepatology

Hello: The antibodies produced by the hepatitis B vaccine are not permanently effective.
Research indicates that some individuals who received the hepatitis B vaccine at birth may not have detectable hepatitis B antibodies by adolescence and may even lose immune memory.
If antibodies are not present, it is recommended to receive a booster dose of the vaccine, followed by a blood test one month later to check for antibody production.
If antibodies are present and at a high titer, it indicates that immune memory is intact, and no further doses are needed.
If antibodies are not detectable, the remaining two doses of the vaccine must be administered.
Since hepatitis B is primarily transmitted through blood, bodily fluids, and sexual contact, individuals such as those undergoing hemodialysis, organ transplant recipients, blood transfusion recipients, immunocompromised individuals, those with multiple sexual partners, intravenous drug users, cohabitants or sexual partners of hepatitis B carriers, and healthcare workers exposed to blood are strongly advised to receive the vaccine.
For individuals at low risk of exposure, vaccination can be considered optional.
Changhua Hospital cares about your health.
Dr.
Tsai An-Shun.

Reply Date: 2012/07/21

More Info

Understanding elevated SGPT (serum glutamic pyruvic transaminase) levels and the implications of hepatitis B antibody testing is crucial for assessing liver health and potential viral infections. Let's break down your questions and concerns regarding your recent lab results and medical history.

1. SGPT Levels: Your SGPT level is reported at 57 IU/L, which is slightly above the normal reference range of 0-55 IU/L. A mild elevation like this, especially if it is only a couple of points above the upper limit, can often be attributed to benign factors such as diet, exercise, or transient liver stress. However, it is essential to consider the context of your overall health, any symptoms you may be experiencing, and other liver function tests. Elevated SGPT levels can indicate liver inflammation or damage, but a slight increase does not necessarily mean you have a serious condition. It is advisable to follow up with your healthcare provider to interpret these results in conjunction with other tests, such as SGOT (serum glutamic oxaloacetic transaminase), bilirubin levels, and any imaging studies like an abdominal ultrasound.

2. Hepatitis B Antibody Testing: Your history of having no detectable hepatitis B antibodies (anti-HBs) during a blood test in elementary school raises important considerations. The absence of these antibodies suggests that you may not have developed immunity to hepatitis B, either due to not being vaccinated or a lack of response to the vaccine. The recommendation from your family physician to receive a booster shot is prudent, especially if you are at risk for hepatitis B exposure.
If your recent blood tests show that you still do not have detectable anti-HBs after vaccination, it may indicate that your body did not respond adequately to the vaccine. In such cases, revaccination or further evaluation may be necessary. The Centers for Disease Control and Prevention (CDC) recommends that individuals who remain at risk for hepatitis B, particularly those with elevated liver enzymes or other risk factors, should consider additional vaccination or monitoring.

3. Next Steps: Since you have already undergone further testing for hepatitis B and C, and are scheduled for an abdominal ultrasound, it is essential to wait for these results to get a clearer picture of your liver health. If your tests indicate ongoing liver inflammation or if you have risk factors for hepatitis B, your healthcare provider may recommend additional vaccinations or treatments.

In summary, while a slight elevation in SGPT may not be alarming, it warrants further investigation, especially in the context of your hepatitis B antibody status. If you continue to have no detectable antibodies after vaccination, discussing the possibility of revaccination or alternative preventive measures with your healthcare provider is advisable. Regular monitoring and follow-up are key to managing your liver health effectively.

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