Should You Get a CA-125 Blood Test for an Ovarian Cyst? - Obstetrics and Gynecology

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Is it necessary to perform a CA-125 blood test when an ovarian cyst is discovered?


I had an ultrasound examination in the obstetrics and gynecology department yesterday, which revealed a 3.6 cm cyst on my left ovary.
However, the doctor only advised me to return for a follow-up in three months.
Should I go to a larger hospital to have a CA-125 blood test?

NINI, 40~49 year old female. Ask Date: 2012/09/05

Dr. Dong Yuhong reply Obstetrics and Gynecology


Hello: Most ovarian cysts smaller than 4 centimeters are functional cysts, so the doctor has recommended a follow-up appointment in three months to monitor any changes in the cyst.
Functional cysts have the potential to resolve on their own.
For ovarian tumors that may arise due to pathological changes, the doctor will conduct appropriate examinations, one of which is the CA-125 test.
Diagnosing a condition requires a process, so it is advisable to cooperate and discuss with your physician.
Thank you!

Reply Date: 2012/09/05

More Info


When it comes to ovarian cysts, particularly functional cysts that are less than 4 cm in size, the general medical consensus is that they often do not require immediate intervention or extensive testing, such as a CA-125 blood test. In your case, the ultrasound revealed a 3.6 cm cyst on your left ovary, and your doctor has recommended a follow-up appointment in three months to monitor the situation. This is a common approach, as many functional cysts can resolve on their own without any treatment.

The CA-125 test is a blood test that measures the level of cancer antigen 125, a protein that can be elevated in certain conditions, including ovarian cancer, endometriosis, and pelvic inflammatory disease. However, it is important to note that CA-125 is not a definitive test for ovarian cancer; elevated levels can occur in benign conditions as well. For instance, menstruation, pregnancy, and other non-cancerous conditions can lead to increased CA-125 levels. Therefore, the test is typically used in conjunction with other diagnostic tools, such as imaging studies and clinical evaluations, rather than as a standalone diagnostic measure.

In your situation, since the cyst is relatively small and your doctor has opted for a watchful waiting approach, it may not be necessary to pursue a CA-125 test at this time. The recommendation to return in three months for follow-up is standard practice, allowing for observation of any changes in the cyst's size or characteristics. If the cyst were to grow significantly or if you were to experience concerning symptoms, further evaluation, including a CA-125 test, might then be warranted.

It is also worth considering that if you have other symptoms, such as persistent abdominal pain, changes in your menstrual cycle, or any other unusual signs, you should communicate these to your healthcare provider. They may decide that additional testing, including the CA-125, is appropriate based on your clinical picture.

In summary, while the CA-125 test can provide useful information in certain contexts, it is not always necessary for every case of ovarian cysts, especially when the cyst is small and asymptomatic. Your doctor's plan for follow-up in three months is a reasonable approach, allowing for careful monitoring without unnecessary intervention. Always feel free to discuss your concerns and preferences with your healthcare provider, as they can provide personalized advice based on your specific medical history and current health status.

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