Elevated Liver Enzymes: What You Need to Know - Gastroenterology and Hepatology

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Concerns about health check-ups?


Hello Doctor: I just completed my annual health check-up this month, and my GOT (AST) and GPT (ALT) levels are both above the standard values, with GOT at 42 and GPT at 86.
Additionally, my total bilirubin is 1.2.
What aspects should I pay attention to for adjustments, or do I need to seek medical treatment or medication? Please help me analyze this.
Thank you!

Jason, 20~29 year old female. Ask Date: 2012/09/16

Dr. Chen Shidian reply Gastroenterology and Hepatology


Hello Jason: Please bring your health check-up report to the Department of Hepatobiliary and Gastroenterology for further evaluation of the elevated indices and treatment.
Changhua Hospital cares about your health~~~~

Reply Date: 2012/09/16

More Info


Elevated liver enzymes, specifically AST (GOT) and ALT (GPT), can be indicative of liver inflammation or damage. In your case, with AST at 42 and ALT at 86, both values are above the normal range, which typically suggests some level of liver dysfunction. The total bilirubin level of 1.2 is within the normal range, which is a positive sign, as it indicates that there is no significant obstruction in the bile ducts or severe liver dysfunction at this time.

When interpreting elevated liver enzymes, it is essential to consider several factors, including the patient's medical history, lifestyle, and any potential risk factors for liver disease. Common causes of elevated liver enzymes include:
1. Alcohol Consumption: Excessive alcohol intake can lead to alcoholic liver disease, which is characterized by elevated liver enzymes. If you consume alcohol, consider reducing or eliminating it from your diet.

2. Non-Alcoholic Fatty Liver Disease (NAFLD): This condition is becoming increasingly common, especially in individuals who are overweight or have metabolic syndrome. It is characterized by fat accumulation in the liver and can lead to inflammation and scarring.

3. Viral Hepatitis: Hepatitis A, B, and C can cause elevated liver enzymes. If you have risk factors for viral hepatitis, such as unprotected sex or sharing needles, it may be worth getting tested.

4. Medications and Supplements: Certain medications, including over-the-counter pain relievers like acetaminophen, can cause liver damage if taken in excess. Herbal supplements can also be hepatotoxic.

5. Autoimmune Liver Disease: Conditions like autoimmune hepatitis can lead to elevated liver enzymes and require specific treatment.

6. Hemochromatosis: This genetic condition leads to excessive iron accumulation in the body, which can damage the liver.

Given your elevated liver enzymes, it is advisable to take the following steps:
- Consult a Healthcare Provider: Schedule an appointment with a healthcare provider, preferably a gastroenterologist or hepatologist, for a thorough evaluation. They may recommend additional tests, such as liver function tests, imaging studies (like an ultrasound), or even a liver biopsy if necessary.

- Lifestyle Modifications: Consider making lifestyle changes, such as adopting a balanced diet rich in fruits, vegetables, and whole grains, while reducing saturated fats and sugars. Regular physical activity can also help maintain a healthy weight and improve liver health.

- Avoid Alcohol and Toxins: If you consume alcohol, it is crucial to stop, as it can exacerbate liver damage. Additionally, avoid exposure to environmental toxins and certain medications that may harm the liver.

- Monitor Symptoms: Keep an eye on any symptoms that may arise, such as jaundice (yellowing of the skin and eyes), fatigue, abdominal pain, or changes in stool color. Report these to your healthcare provider promptly.

- Regular Follow-Up: Regular monitoring of liver enzymes and overall liver function is essential to track any changes and determine the effectiveness of any interventions.

In conclusion, while elevated liver enzymes can be concerning, they do not always indicate severe liver disease. With appropriate lifestyle changes and medical guidance, many individuals can improve their liver health and prevent further complications. Always consult with a healthcare professional for personalized advice and treatment options tailored to your specific situation.

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