Delayed HSV-2 Test Results: What You Need to Know - Urology

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Herpes inquiry


Doctor, I had a high-risk exposure (with condom use) and tested negative for HSV-2 in the first month at Lab A, with a result of 0.5 (-).
The reference ranges were negative <0.9, equivocal 0.91-1.09, and positive >1.1.
In the second month, I tested negative again at Lab B, with a result of 4.4 (-) RU/ml.
In the third month, I tested negative at Lab C, with HSV IgG at 12.6 (-) and IgM at 0.194 (<0.548).
I planned to do a final test after six months for peace of mind, and today the report came back from Lab A showing HSV-2 at 15.00 (+), with the same reference ranges.
Is it possible for the virus to appear after such a long time? Moreover, I tested positive for herpes six months later, despite having no clinical symptoms during this period, except for balanitis, which was confirmed by a doctor.
All other tests were normal, leaving me with little confidence in the normal results.
I feel severely depressed and as if it's the end of the world...
I have thoughts of wanting to die.
Currently, I am single and unmarried, and I worry about potentially transmitting this to my future wife or children.
Please respond, doctor...
Thank you.

ken, 20~29 year old female. Ask Date: 2012/10/16

Dr. Xu Weikai reply Urology


Ken: Hello, I don't understand why everyone is so afraid of herpes.
In Taiwan, the overall carrier rate is about 75-90%.
In other words, if you test 100 people, around 80 of them will have a positive IgG result.
Even if you do contract herpes, unless your immune system is very weak, there is really no need for any treatment.
I truly wonder why people are so fearful of herpes; what is there to be afraid of? Given the current situation in Taiwan, there is no need to fear transmission, as most people have already been infected at some point, and the virus is still present in their bodies.

Reply Date: 2012/10/16

More Info


Understanding the complexities of HSV-2 (Herpes Simplex Virus type 2) testing can be quite challenging, especially when faced with fluctuating test results and the emotional burden that often accompanies such concerns. Based on the information you've provided, let's break down the key points regarding HSV-2 testing, the implications of your results, and what steps you might consider moving forward.


Test Results Interpretation
1. Initial Negative Results: Your first two tests showing negative results for HSV-2 (0.5 and 4.4) suggest that you were not infected at those times. The reference ranges you provided indicate that values below 0.9 are considered negative, and your results were well within that range.

2. Subsequent Positive Result: The significant jump to a positive result (15.00) in your latest test raises questions about the timing of the infection. It's important to note that HSV-2 can sometimes take time to produce detectable antibodies, which is why a negative result does not definitively rule out an infection, especially if the test is done shortly after potential exposure.

3. IgG vs. IgM Testing: IgG antibodies indicate a past infection, while IgM antibodies are typically associated with recent infections. Your IgM result (0.194) suggests that you are not currently experiencing a primary infection. The presence of IgG antibodies (12.6) indicates that you have been exposed to the virus at some point, but it does not necessarily mean you are currently infectious or symptomatic.


Clinical Symptoms and Asymptomatic Carriers
- Asymptomatic Nature of HSV: Many individuals with HSV-2 are asymptomatic, meaning they do not exhibit any noticeable symptoms such as sores or blisters. This is quite common, and many people may carry the virus without ever experiencing an outbreak. The fact that you have not had any clinical symptoms over the past six months is consistent with this.

- Glandular or Other Infections: The episode of glans inflammation you mentioned could be due to other causes unrelated to HSV-2, such as irritation or a different type of infection. It’s crucial to have a healthcare provider evaluate any symptoms to determine their cause accurately.


Emotional Impact and Future Considerations
- Mental Health: The anxiety and distress you are experiencing are understandable given the uncertainty surrounding HSV-2. It’s essential to address these feelings, as they can significantly impact your quality of life. Consider speaking with a mental health professional who can help you navigate these emotions and provide coping strategies.

- Transmission Risks: If you are indeed infected with HSV-2, it is possible to transmit the virus to a sexual partner, even when asymptomatic. However, the risk of transmission is lower when no symptoms are present, and using protection (like condoms) can further reduce this risk. Open communication with future partners about your HSV status is crucial.


Recommendations Moving Forward
1. Follow-Up Testing: Given the discrepancies in your test results, it may be beneficial to consult with a healthcare provider for further testing. They may recommend a different type of test or retesting after a certain period to confirm your status.

2. Education and Awareness: Educate yourself about HSV-2, its transmission, and management. Understanding the virus can help alleviate some fears and empower you to make informed decisions regarding your health and relationships.

3. Consult a Specialist: If you have ongoing concerns, consider seeing a specialist in infectious diseases or a dermatologist who can provide more insight into your situation and help you manage any potential symptoms or concerns.

In conclusion, while the positive HSV-2 test result may be alarming, it’s essential to interpret it in the context of your overall health, symptoms, and the nature of the virus. With the right information and support, you can navigate this situation effectively.

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