the Impact of Angina and Osteoporosis on Heart Health - Cardiology

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Angina and osteoporosis?


Dear Director He,
Earlier this year, I underwent surgery for primary hyperparathyroidism due to severe osteoporosis and high blood calcium levels, and my calcium levels returned to normal postoperatively.
I have been taking calcium supplements and vitamin D.
In mid-March, I experienced chest pain, and a myocardial perfusion study revealed signs of hypoxia.
My doctor prescribed Herbesser 30 mg and Sigmart 5 mg, to be taken three times daily, one tablet each time.
After more than six months of this treatment, I felt some improvement.
However, this month I have been experiencing mild pain and warmth in my chest and ribs, as well as similar mild pain when exerting my wrists.
I returned to the original physician who diagnosed my high blood calcium, and tests showed that my calcium, phosphorus, and parathyroid hormone levels are all normal.
Could you please advise if these two cardiovascular medications affect calcium absorption or worsen osteoporosis? Additionally, my endocrinologist has prescribed Ismo-20 (20 mg, half a tablet in the morning and evening) and Diovan FC (160 mg, half a tablet daily) and suggested that I switch to these heart medications.
Since my cardiology appointment is still some time away, I would greatly appreciate your insights.
Thank you.

Nanping, 50~59 year old female. Ask Date: 2012/10/18

Dr. He Dongjin reply Cardiology


Hello, as far as I know, these medications can affect calcium absorption or parathyroid function.
You may consider undergoing a 64-slice CT scan or cardiac catheterization to assess your cardiovascular status.
If there are no significant issues, the related medications can be reduced, which may also alleviate your concerns.
Changhua Hospital cares about you.

Reply Date: 2012/10/18

More Info


Understanding the interplay between angina and osteoporosis is crucial for managing heart health, especially in patients with a history of cardiovascular issues and metabolic bone diseases. In your case, the recent diagnosis of angina, coupled with a history of severe osteoporosis and hyperparathyroidism, presents a unique challenge.

Angina, or chest pain due to reduced blood flow to the heart, can be exacerbated by various factors, including stress, physical exertion, and underlying health conditions. The myocardial perfusion scan indicating hypoxia suggests that your heart is not receiving adequate oxygen, which is a significant concern. The medications prescribed, Herbesser (a beta-blocker) and Sigmart (a vasodilator), are commonly used to manage angina by improving blood flow and reducing heart workload.
On the other hand, osteoporosis is characterized by decreased bone density and increased fracture risk. The concern about whether cardiovascular medications might affect calcium absorption or worsen osteoporosis is valid. Generally, beta-blockers like Herbesser do not have a direct negative impact on bone health. However, some studies suggest that long-term use of certain medications, particularly corticosteroids or excessive use of proton pump inhibitors, can adversely affect calcium metabolism and bone density.
The medications you mentioned, Ismo (an isosorbide mononitrate) and Diovan (an angiotensin receptor blocker), are also not typically associated with negative effects on bone health. In fact, some studies have indicated that certain antihypertensive medications may have a neutral or even beneficial effect on bone density. However, it is essential to monitor your overall health, including calcium and vitamin D levels, especially since you have a history of hyperparathyroidism, which can complicate calcium metabolism.

Given your symptoms of rib pain and wrist discomfort, it is crucial to differentiate between musculoskeletal pain and potential cardiac-related issues. Rib pain can sometimes be associated with angina, especially if it radiates or is accompanied by other symptoms like shortness of breath or fatigue. However, if the pain is localized and does not follow the typical pattern of angina, it may be musculoskeletal in nature, possibly related to osteoporosis or muscle strain.

In terms of managing your osteoporosis, continuing calcium and vitamin D supplementation is vital. Engaging in weight-bearing exercises, as tolerated, can also help improve bone density. It's essential to have regular follow-ups with your healthcare provider to monitor your bone health and adjust your treatment plan as necessary.

In conclusion, while the medications you are taking for your heart condition are not likely to exacerbate osteoporosis, it is essential to maintain a holistic approach to your health. Regular monitoring of your cardiovascular status and bone health, along with a balanced diet rich in calcium and vitamin D, will be critical in managing both conditions effectively. If you have concerns about your medications or symptoms, it would be prudent to consult with your healthcare provider for personalized advice and potential adjustments to your treatment plan.

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