Pregnant After Hepatitis B Vaccination: What You Need to Know - Obstetrics and Gynecology

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Hello Doctor: I received the hepatitis B vaccine last week, but I found out I am pregnant this week.
What should I do? Will it be harmful to the baby? Should I continue with the vaccination? Thank you.

Ru Ru, 30~39 year old female. Ask Date: 2012/12/30

Dr. Lin Wenbin reply Obstetrics and Gynecology


Inactivated vaccines or toxoid vaccines can be administered during pregnancy.
The hepatitis B vaccine is classified as an inactivated vaccine (non-live), so it is safe to receive during pregnancy.
The hepatitis B vaccine series consists of three doses (administered at 0, 1, and 6 months), and if there are any remaining doses that have not been received, they can still be administered during pregnancy.

Reply Date: 2012/12/30

More Info


When it comes to the concerns surrounding pregnancy after receiving the Hepatitis B vaccine, it is important to understand the nature of the vaccine and its implications for both the mother and the developing fetus. The Hepatitis B vaccine, known as "Engerix-B" in English, is an inactivated (or killed) virus vaccine. This means that it does not contain live virus particles that could potentially cause infection. As such, it is generally considered safe for administration during pregnancy.

The standard vaccination schedule for the Hepatitis B vaccine consists of three doses: the first dose is given at 0 months, the second dose at 1 month, and the third dose at 6 months. Each dose typically contains 20 micrograms of the vaccine. If you have received the first two doses and have just discovered your pregnancy, there is no need for alarm. The vaccine does not pose a risk to the fetus, and it is recommended that you complete the vaccination series as planned, unless otherwise advised by your healthcare provider.

Research indicates that inactivated vaccines, including the Hepatitis B vaccine, do not have adverse effects on pregnancy outcomes. The Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) both support the use of the Hepatitis B vaccine during pregnancy when indicated. The benefits of vaccination, particularly for women at risk of Hepatitis B infection, far outweigh any potential risks.

If you are concerned about the timing of your vaccination in relation to your pregnancy, it is advisable to consult with your healthcare provider. They can provide personalized guidance based on your medical history and any specific risk factors you may have. Generally, it is recommended to wait at least three months after receiving the Hepatitis B vaccine before attempting to conceive, as a precautionary measure. However, since you have already received the vaccine and are now pregnant, the focus should be on ensuring a healthy pregnancy and completing the vaccination series as needed.

In addition to the Hepatitis B vaccination, it is essential to maintain regular prenatal care throughout your pregnancy. This includes routine blood tests, ultrasounds, and other screenings to monitor the health of both you and your baby. If you have any underlying health conditions or concerns, such as being a carrier of Hepatitis B, your healthcare provider can help you develop a management plan to minimize any risks to your baby.

In summary, receiving the Hepatitis B vaccine shortly before discovering your pregnancy is not a cause for concern. The vaccine is safe for pregnant women, and completing the vaccination series is important for your health and the health of your baby. Always consult with your healthcare provider for tailored advice and to address any specific questions or concerns you may have regarding your pregnancy and vaccination status.

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