Yellowing of the Whites of the Eyes: Causes and Solutions - Ophthalmology

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Issues with the sclera?


Is it possible for someone to experience yellowing of the sclera or changes in eye color due to cosmetics? Additionally, if a medication can cause pigmentation, is it advisable to avoid using it?

luili, 10~19 year old female. Ask Date: 2001/08/29

Dr. Huang Bozhen reply Ophthalmology


The first consideration for yellowing of the sclera is whether there is liver disease.
Only after confirming that there is no liver disease should other causes be considered.
As for whether cosmetics can cause this condition, there are currently no reports indicating so.
Additionally, it is best to avoid using eye drops unless there is a specific eye condition that necessitates their use; this should be determined by a physician.

Reply Date: 2001/08/29

More Info


The yellowing of the whites of the eyes, medically known as scleral icterus, can be attributed to various factors, including liver dysfunction, certain medications, and even cosmetic products. Understanding the underlying causes is essential for determining appropriate solutions and management strategies.

Causes of Yellowing of the Eyes:
1. Liver Dysfunction: One of the most common causes of yellowing in the eyes is jaundice, which occurs when there is an accumulation of bilirubin in the bloodstream. This can be due to liver diseases such as hepatitis, cirrhosis, or bile duct obstruction. When the liver is unable to process bilirubin effectively, it can lead to a yellow tint in the sclera (the white part of the eye).

2. Medications: Certain medications can cause yellowing of the eyes as a side effect. For instance, some antibiotics and anti-inflammatory drugs can lead to changes in liver function or cause the skin and eyes to appear yellow. If you suspect that a medication may be causing this symptom, it is crucial to consult with a healthcare provider for an evaluation.

3. Cosmetic Products: While it is less common, some cosmetic products, particularly those containing dyes or certain chemicals, can potentially lead to discoloration of the sclera. If you have recently started using new makeup or skincare products around the eyes, it may be worth considering whether these could be contributing to the yellowing.

4. Other Health Conditions: Conditions such as hemolytic anemia, where red blood cells are destroyed faster than they can be made, can also lead to increased bilirubin levels and subsequent yellowing of the eyes. Additionally, certain genetic conditions can affect how the body processes bilirubin.

Solutions and Recommendations:
1. Consult a Healthcare Provider: If you notice yellowing of the whites of your eyes, it is essential to seek medical advice. A healthcare provider can perform a thorough examination, including blood tests to assess liver function and bilirubin levels, to determine the underlying cause.

2. Review Medications: If you suspect that a medication may be causing the yellowing, discuss this with your doctor. They may suggest alternative treatments or adjust dosages as necessary.

3. Evaluate Cosmetic Use: If you believe that cosmetic products may be contributing to the discoloration, consider discontinuing their use and monitoring for any changes. Opt for hypoallergenic or non-comedogenic products that are less likely to cause irritation or discoloration.

4. Protect Your Eyes: To minimize potential irritation from environmental factors or products, consider wearing sunglasses when outdoors and using gentle, non-irritating eye drops if your eyes feel dry or uncomfortable.

5. Regular Eye Exams: Regular visits to an eye care professional can help monitor your eye health and catch any potential issues early. This is particularly important if you have a history of liver disease or other health conditions that could affect your eyes.

In summary, yellowing of the whites of the eyes can be caused by various factors, including liver dysfunction, medications, and cosmetic products. It is crucial to consult with a healthcare provider to determine the underlying cause and receive appropriate treatment. Taking proactive steps, such as reviewing medications and cosmetic use, can help manage and potentially alleviate this symptom.

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