Long-Term Use of Eye Drops for Allergies: Safety and Recommendations - Ophthalmology

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Usage of Eye Drops


Hello, Doctor Gao.
I have a question regarding eye drops.
My daughter, who is 10 years old, has been experiencing allergy symptoms, including daily sneezing and itchy eyes.
My wife has been using a type of eye drops called Spersallerg, which contains the following ingredients: Antazoline Hydrochloride, which acts as an antihistamine to reduce allergic reactions, and Tetrahydrozoline Hydrochloride, which is a vasoconstrictor that alleviates inflammation and swelling of the conjunctiva.
Is it safe for her to use these drops long-term? How many times a day can she use them? Additionally, someone suggested using Alcon's Patanol (Olopatadine).
Is it safe for long-term use as well?

Mr. Wang, 40~49 year old female. Ask Date: 2013/08/12

Dr. Gao Pilin reply Ophthalmology


Hello: According to the precautions on the Spersallerg package insert, this product is not intended for long-term use.
If the expected treatment duration exceeds 2-3 days, a physician's prescription and follow-up examination are required.
Due to the presence of a vasoconstrictor, it is not suitable for prolonged use.

Dosage/Administration: This medication must be prescribed by a physician.
During acute episodes, instill one drop every 3 hours as a maintenance therapy 2-3 times daily, with each dose being one drop.
For children, the dosage is 1-2 drops daily.
Therefore, for a 10-year-old child, the limit is two doses per day.
Please refer to: http://mab.mnd.gov.tw/med/efiles/B019012429.pdf
======================================
Patanol R 0.1% is a sterile ophthalmic solution containing olopatadine, which is a relatively selective H1 receptor antagonist administered topically to the eyes and can inhibit the release of histamine from mast cells.
Due to its purely antihistaminic action, it is more suitable for long-term use; however, regular follow-up is still recommended.
The suggested dosage is to instill one drop into the affected eye twice daily.
Please refer to: http://www.alcon.com.tw/consumer/consumer_products.asp?class_id=1&aa=%B2%B4%AC%EC%A5%CE%C3%C4&kind_id=7&xx=%B9L%B1%D3%AAv%C0%F8%BE%AF&prod_id=57
Thank you for your inquiry.

Reply Date: 2013/08/12

More Info


When it comes to the long-term use of eye drops for allergies, particularly in children, it is crucial to consider both the active ingredients and the potential side effects associated with prolonged use. In your case, your daughter has been using Spersallerg eye drops, which contain Antazoline Hydrochloride and Tetrahydrozoline Hydrochloride.
Antazoline is an antihistamine that helps reduce allergic reactions by blocking histamine receptors, while Tetrahydrozoline is a vasoconstrictor that alleviates redness and swelling in the eyes by constricting blood vessels. While these components can provide relief from allergy symptoms, their long-term use raises some concerns.

Safety of Long-Term Use:
1. Antihistamines (Antazoline Hydrochloride): While antihistamines are generally safe for short-term use, long-term use can lead to tolerance, meaning that over time, the effectiveness may diminish. Additionally, some antihistamines can cause dryness in the eyes, which may exacerbate symptoms in the long run.

2. Vasoconstrictors (Tetrahydrozoline Hydrochloride): The use of vasoconstrictors for extended periods can lead to rebound redness. This means that after the medication wears off, the redness may return even worse than before, leading to a cycle of dependency on the drops. This is particularly concerning in children, as their eyes are more sensitive.

Recommendations:
- Consult an Eye Specialist: It is essential to have regular check-ups with an ophthalmologist or an allergist who can assess your daughter's condition and recommend appropriate treatments. They may suggest alternative therapies or medications that are safer for long-term use.


- Consider Alternative Medications: Patanol (Olopatadine) is an antihistamine eye drop that is often recommended for allergic conjunctivitis. It is generally considered safe for long-term use and can be used twice daily. It may be a better option for your daughter, as it is specifically designed for treating allergy symptoms without the rebound effect associated with vasoconstrictors.

- Non-Pharmacological Approaches: In addition to medication, consider implementing non-pharmacological strategies to manage allergy symptoms. This can include keeping windows closed during high pollen seasons, using air purifiers, and ensuring that your daughter avoids known allergens.

- Dosage and Frequency: If you continue with Spersallerg, it is crucial to follow the recommended dosage. Typically, these drops can be used 2-3 times a day, but this should be confirmed with a healthcare provider. Overuse can lead to complications, so it is essential to adhere to prescribed guidelines.

In summary, while Spersallerg may provide temporary relief for your daughter's allergy symptoms, its long-term use is not advisable due to the potential for rebound effects and other side effects. Consulting with a healthcare professional about alternative treatments, such as Patanol, and exploring non-pharmacological strategies will be beneficial in managing her symptoms effectively and safely. Regular follow-ups will ensure that her treatment plan remains appropriate as she grows and her needs change.

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