Elevated Diastolic Blood Pressure After Medication Change - Cardiology

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Regarding elevated diastolic blood pressure?


Hello Doctor, due to concerns about the long-term side effects of antihypertensive medications, I discussed with my physician and switched to another blood pressure medication that is considered to have fewer concerns.
However, since starting this new medication, my blood pressure has increased from an average of around 120/75 to about 135/95.
Although the systolic pressure is on the borderline, I am wondering why the diastolic pressure remains elevated? I have been on this new medication for about five months.
I discussed this situation with my physician, who suggested monitoring it for a while longer, considering I had been on the previous medication for over three years, allowing my body some time to adjust.
My father also mentioned that during the first six months of taking blood pressure medication, his readings fluctuated significantly, but after some time, his blood pressure stabilized around 110/70.
Additionally, I have lost a considerable amount of weight (about 20 kg), and my doctor reduced my dosage when switching medications.
Furthermore, my mother has a history of hypertension.
I wonder if these various factors could be contributing to my current blood pressure instability? I also noticed that during the first three months on this new medication, my heart rate was consistently between 85 and 95, but recently it seems to have adjusted, and my heart rate is now between 65 and 70.
Should I be more patient and continue to monitor my condition? Although my BMI has decreased by about 7.5, I still need to lose about 5 more kilograms to reach a normal weight.
If I successfully reach a normal weight, will my blood pressure effectively decrease? *Since I started taking blood pressure medication, I have only been on one pill and I regularly exercise.

EE, 20~29 year old female. Ask Date: 2013/08/22

Dr. He Dongjin reply Cardiology


Hello, you should be able to maintain the medication dosage for continuous weight loss, and it is likely to decrease further.
Regular exercise is more practical.
Changhua Hospital cares about you.

Reply Date: 2013/08/22

More Info


Elevated diastolic blood pressure after a medication change can be a concerning issue, especially for someone with a history of hypertension. In your case, you mentioned that after switching to a new antihypertensive medication, your blood pressure readings shifted from an average of 120/75 mmHg to 135/95 mmHg. While systolic blood pressure (the top number) is still within an acceptable range, the elevated diastolic blood pressure (the bottom number) can pose risks, particularly for cardiovascular health.

There are several factors that could contribute to this change in blood pressure readings. Firstly, the new medication may have a different pharmacological profile compared to your previous medication. Some antihypertensive drugs are more effective at lowering systolic blood pressure than diastolic blood pressure. For instance, certain calcium channel blockers or diuretics may have a more pronounced effect on systolic pressure, while others, like ACE inhibitors or ARBs, might provide a more balanced reduction in both systolic and diastolic pressures. If your new medication is less effective at lowering diastolic pressure, this could explain the change you are observing.

Additionally, the body often requires time to adjust to new medications. As your physician suggested, it can take several months for your body to adapt to a new antihypertensive regimen. This adjustment period can lead to fluctuations in blood pressure readings, and it is not uncommon for patients to experience variability in their blood pressure during this time. Your father's experience, where his blood pressure stabilized after several months on medication, supports this notion.

Weight loss can also play a significant role in blood pressure management. You mentioned that you have lost about 20 kg and are still aiming to reach your target weight. Weight loss is generally associated with improved blood pressure control, and achieving a healthy BMI can further enhance the effectiveness of antihypertensive medications. As you continue to lose weight, you may find that your blood pressure readings improve, potentially leading to a reduction in both systolic and diastolic pressures.

It's also worth considering lifestyle factors that can influence blood pressure. Regular physical activity, a balanced diet low in sodium, and stress management techniques can all contribute to better blood pressure control. Since you mentioned that you have been consistently exercising, this is a positive step toward maintaining healthy blood pressure levels.

Regarding your heart rate, the decrease from 85-95 beats per minute to 65-70 beats per minute is a notable change. A lower resting heart rate can be a sign of improved cardiovascular fitness, especially if you are engaging in regular aerobic exercise. However, if you experience any symptoms such as dizziness, fatigue, or palpitations, it would be prudent to discuss these changes with your healthcare provider.

In summary, while the increase in diastolic blood pressure after changing medications is concerning, it is essential to consider the adjustment period, the specific effects of the new medication, and the positive impact of weight loss and lifestyle changes. Continue to monitor your blood pressure and maintain open communication with your healthcare provider. If your blood pressure does not stabilize or continues to rise, further adjustments to your medication regimen may be necessary. Patience and ongoing observation are key, as your body may still be adapting to the new treatment.

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