Iron Supplement Dosage for Anemia: Safety and Guidelines - Cardiology

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Issues with Iron Supplementation


Hello Doctor: I have severe iron deficiency anemia, and my doctor prescribed "Buli'an Chewable Tablets 100 mg" (terrain tablet 100mg Fe/tab), to be taken one tablet in the morning and one in the evening.
However, there are medical reports stating that the daily dosage of iron supplements should not exceed 45 mg, as exceeding this amount may increase the burden on the liver.
Is this true? If so, does the 100 mg in the iron supplement I am taking indicate that I am exceeding the recommended dosage? What should I do? Thank you for your guidance.

Miss Lin, 40~49 year old female. Ask Date: 2013/09/17

Dr. He Dongjin reply Cardiology


Hello, your anemia seems to be quite severe, which is why the doctor advised you to take the medication twice.
There are concerns about increasing the burden on your liver.
If you are worried, you can at least take one pill a day and supplement your diet with high-iron foods such as meat and raisins.
Changhua Hospital cares about you.

Reply Date: 2013/09/17

More Info


When it comes to iron supplementation for treating iron deficiency anemia, it's crucial to understand both the appropriate dosage and the potential risks associated with excessive iron intake. Your concern regarding the dosage of "補立安咀嚼錠" (Terrain tablet 100mg Fe/tab) is valid, especially given the conflicting information regarding daily iron intake limits.

Iron is an essential mineral that plays a vital role in the formation of hemoglobin, which is necessary for transporting oxygen in the blood. In cases of iron deficiency anemia, healthcare providers often prescribe iron supplements to help restore adequate iron levels. The recommended dietary allowance (RDA) for iron varies based on age, sex, and life stage. For adult men, the RDA is about 8 mg per day, while for adult women, especially those who are menstruating, it can be as high as 18 mg per day. However, in cases of diagnosed iron deficiency anemia, higher doses may be necessary.

The typical therapeutic dose for iron supplements can range from 100 mg to 200 mg of elemental iron per day, depending on the severity of the deficiency and the individual's response to treatment. The iron in your supplement, "補立安咀嚼錠," is 100 mg per tablet, which means that taking one tablet twice a day would provide a total of 200 mg of elemental iron daily. This dosage is often considered safe and effective for treating iron deficiency anemia, particularly in cases where the deficiency is significant.

However, your concern about the potential for liver overload and toxicity is not unfounded. The general guideline you mentioned, which states that daily iron intake should not exceed 45 mg to avoid liver strain, is more applicable to the general population and not specifically to those undergoing treatment for iron deficiency anemia. In fact, the upper limit for iron supplementation in adults is often cited as 45 mg per day to prevent adverse effects in individuals who do not have iron deficiency.

For individuals who are being treated for iron deficiency anemia, the risk of iron overload is a concern, particularly if supplementation is continued beyond the necessary duration or if there are underlying conditions that affect iron metabolism, such as hemochromatosis. Therefore, it is essential to monitor iron levels through blood tests, including serum ferritin and transferrin saturation, to ensure that iron levels are returning to normal and to adjust the dosage accordingly.

If you are concerned that the dosage you are taking may be excessive, it is advisable to discuss this with your healthcare provider. They may recommend periodic blood tests to monitor your iron levels and adjust your supplementation as needed. Additionally, they may suggest dietary modifications to include iron-rich foods, such as red meat, poultry, fish, lentils, beans, and fortified cereals, which can help improve your iron status without the risks associated with high-dose supplementation.

In summary, while the dosage of 200 mg of elemental iron per day may be appropriate for treating your iron deficiency anemia, it is essential to have regular follow-ups with your healthcare provider to monitor your iron levels and ensure that you are not at risk for iron overload. Always communicate any concerns you have regarding your treatment plan, and do not hesitate to seek clarification from your physician.

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