Abnormal Pregnancy Test Results: AFP and White Blood Cell Counts - Obstetrics and Gynecology

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Understanding abnormal pregnancy test results can be a source of anxiety for expectant mothers, especially when it comes to interpreting values such as Alpha-fetoprotein (AFP) and white blood cell counts. In your case, you mentioned that your AFP level is 18.91, which is significantly higher than the typical reference range of 0-7. Additionally, you noted that your neutrophil count is elevated at 83.8%, while your basophil count is low at 11.8%.
Firstly, let's discuss the AFP levels. AFP is a protein produced by the fetal liver, and its levels can be measured in the mother's blood during pregnancy. Elevated AFP levels can indicate several conditions, including neural tube defects, abdominal wall defects, or even multiple gestations. However, it is important to note that elevated AFP levels do not automatically indicate a problem. The interpretation of AFP levels should be done in conjunction with other factors, such as the gestational age of the fetus, the mother's age, and the results of other screening tests, such as the first-trimester Down syndrome screening you mentioned, which was normal.

In your case, the AFP level of 18.91 is indeed elevated, but it is crucial to consider this result in the context of your overall pregnancy and any additional tests you have undergone. Since you have already had normal results from the first-trimester screening and nuchal translucency test, it may be less likely that there is a significant issue. However, it is advisable to discuss these results with your healthcare provider, who may recommend further testing or monitoring to ensure everything is progressing normally.

Now, regarding your white blood cell counts, the neutrophil percentage of 83.8% is elevated, which can indicate an ongoing infection or inflammation. During pregnancy, it is common for the body to experience changes in immune function, and white blood cell counts can fluctuate. An elevated neutrophil count can be a normal physiological response to pregnancy, but it can also suggest an infection that may need to be addressed. The low basophil count of 11.8% is less concerning, as basophils typically make up a small percentage of the total white blood cell count and can vary widely.

In summary, while your AFP level is elevated and your neutrophil count is high, these results should be interpreted in the context of your overall health and pregnancy. It is essential to have a thorough discussion with your healthcare provider, who can evaluate your specific situation and determine if further testing is necessary. They may suggest additional ultrasounds or blood tests to monitor the health of your fetus and ensure that any potential issues are addressed promptly. Remember, communication with your healthcare team is key to navigating any concerns during your pregnancy.