Medical Test Results: Reference Values and Hemolysis Explained - Family Medicine

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Some questions?


Hello, doctor: We often undergo various health check-ups.
For example, if a report shows a value of 47 and the reference range is >50, what does this reference value mean? Does it mean that only values greater than 50 are considered abnormal? Also, I have G6PD deficiency and I know that consuming certain foods can lead to hemolysis.
What does hemolysis mean? If there is hemolysis in the blood, is the report from the drawn blood still accurate? I apologize for having so many questions.

Zhang Zhengyi, 20~29 year old female. Ask Date: 2013/12/15

Dr. Gao Qingyun reply Family Medicine


Dear Zhengyi,
Hello, the reference values refer to the average concentration of liver enzymes in the blood of healthy adults without disease, which is normal for 95% of the population.
Values exceeding this range may indicate hepatitis or other causes of elevated enzyme levels.
Hemolysis in patients with favism refers to the destruction of red blood cells, which can pose a life-threatening risk and is considered an emergency.
However, if it is not acute hemolysis, the blood test results do not require special consideration.
Thank you.
Wishing you peace and health,
Dr.
Gao Qingyun
Department of Family Medicine
Taoyuan Hospital, Ministry of Health and Welfare

Reply Date: 2013/12/15

More Info


Understanding medical test results can be quite complex, especially when it comes to interpreting reference values and the implications of conditions like hemolysis. Let's break down your questions for clarity.


Reference Values
When you see a test result, such as 47, with a reference value of >50, it indicates that the normal range for that particular test is above 50. In this context, a result of 47 would be considered below the normal range, suggesting that there may be an underlying issue that needs to be addressed. Reference values are established based on a large population of healthy individuals and are used as a benchmark to help healthcare providers determine whether a patient's results fall within a normal range or indicate a potential health problem.


Hemolysis Explained
Hemolysis refers to the destruction of red blood cells (RBCs), which can lead to the release of hemoglobin into the bloodstream. This can occur due to various reasons, including autoimmune disorders, infections, certain medications, and inherited conditions like G6PD deficiency. In individuals with G6PD deficiency, exposure to certain foods (like fava beans), infections, or medications can trigger hemolysis, leading to symptoms such as fatigue, jaundice, and dark urine.


Accuracy of Blood Tests in the Context of Hemolysis
If hemolysis occurs before or during the blood draw, it can affect the accuracy of the test results. For instance, hemolysis can lead to falsely elevated levels of potassium, lactate dehydrogenase (LDH), and other substances in the blood. Therefore, if hemolysis is suspected, healthcare providers may repeat the test to ensure accurate results.

Implications of Your Condition
Given your G6PD deficiency, it is crucial to avoid known triggers that can lead to hemolysis. Regular monitoring of your blood tests is essential to catch any potential issues early. If you notice symptoms such as fatigue, pallor, or jaundice, it is important to seek medical attention promptly.


Next Steps
1. Consult Your Healthcare Provider: Discuss your test results with your healthcare provider to understand their implications fully. They can provide personalized advice based on your medical history and current health status.

2. Monitor Symptoms: Keep track of any symptoms that may arise, especially those related to hemolysis, and report them to your healthcare provider.

3. Dietary Considerations: Be mindful of your diet, avoiding foods and medications that could trigger hemolysis. Your healthcare provider can give you a list of substances to avoid.

4. Regular Check-ups: Schedule regular follow-up appointments to monitor your blood levels and overall health, ensuring that any changes are addressed promptly.

In conclusion, understanding your medical test results, especially in the context of conditions like G6PD deficiency, is vital for maintaining your health. By staying informed and proactive, you can manage your condition effectively and minimize the risk of complications.

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