Medications vs. Surgery for Enlarged Prostate: What’s Best for You? - Urology

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Is it better to treat benign prostatic hyperplasia with medication or surgery?


Hello Doctor: I have benign prostatic hyperplasia (BPH), and my condition has improved with medication, but I am experiencing a lot of side effects such as orthostatic hypotension, gastrointestinal discomfort, dizziness, difficulty with ejaculation, decreased libido, allergies, and edema.
I feel troubled by the thought of having to take medication for life.
Would it be better to consider surgery as a solution? After surgery, will there be many troublesome complications and side effects? I'm unsure how to make a decision, and I would appreciate your guidance.
Thank you!

Niming, 60~69 year old female. Ask Date: 2014/01/02

Dr. Xu Weikai reply Urology


Hello, if the surgery goes smoothly, there may be no need for medication afterward.
However, some individuals may experience prostate enlargement again after 5-10 years, which might require another surgery.
You can choose medications with fewer side effects.
If there are any unclear points, feel free to ask again, and we can discuss and research further.
Information from the internet should only be used as a reference; if necessary, it is important to seek medical care at a healthcare facility.
The Ministry of Health and Welfare Taitung Hospital cares about you.

Reply Date: 2014/01/02

More Info


When considering treatment options for benign prostatic hyperplasia (BPH), it's essential to weigh the benefits and drawbacks of medications versus surgical interventions. BPH is a common condition in older men, characterized by an enlarged prostate that can lead to urinary symptoms such as difficulty urinating, frequent urination, and a weak urine stream.
Medications for BPH:
Medications are often the first line of treatment for BPH. Common classes of medications include alpha-blockers (like tamsulosin) and 5-alpha-reductase inhibitors (like finasteride). Alpha-blockers work by relaxing the muscles around the prostate and bladder neck, making it easier to urinate. In contrast, 5-alpha-reductase inhibitors help shrink the prostate over time by blocking the hormone responsible for prostate growth.

While medications can be effective, they often come with side effects, as you've experienced. These can include:
- Orthostatic hypotension: A drop in blood pressure when standing up, leading to dizziness or fainting.

- Gastrointestinal issues: Such as nausea or abdominal discomfort.

- Sexual side effects: Including erectile dysfunction, decreased libido, and difficulties with ejaculation.

- Allergic reactions and edema: Swelling due to fluid retention.

The need for lifelong medication can be burdensome, especially if side effects significantly impact your quality of life.

Surgical Options:
Surgery may be considered if medications are ineffective or if side effects are intolerable. The most common surgical procedure for BPH is transurethral resection of the prostate (TURP), which involves removing part of the prostate to relieve pressure on the urethra. Other options include laser therapy and minimally invasive techniques.

Benefits of Surgery:
- Immediate Relief: Surgery can provide rapid improvement in urinary symptoms.

- Long-term Solution: Many patients experience long-lasting relief, potentially reducing or eliminating the need for medications.

- Improved Quality of Life: Many men report a significant improvement in their quality of life post-surgery.

Risks and Side Effects of Surgery:
However, surgery is not without risks. Potential complications can include:
- Urinary incontinence: Some men may experience leakage of urine after surgery.

- Erectile dysfunction: While many men maintain sexual function, some may experience difficulties post-surgery.

- Retrograde ejaculation: This occurs when semen enters the bladder instead of exiting through the penis, which can affect fertility.

Making the Decision:
Deciding between medication and surgery involves considering several factors:
1. Severity of Symptoms: If your symptoms are significantly impacting your daily life, surgery may be a more appropriate option.

2. Response to Medications: If medications are effective but causing intolerable side effects, surgery might be a better long-term solution.

3. Overall Health: Your general health and any other medical conditions (like heart disease or diabetes) can influence the safety and appropriateness of surgery.

4. Personal Preferences: Discuss your concerns and preferences with your healthcare provider. They can help you understand the risks and benefits of each option based on your specific situation.

In conclusion, both medications and surgery have their place in the management of BPH. If medications are causing significant side effects and you are seeking a more permanent solution, discussing surgical options with your urologist may be beneficial. They can provide personalized recommendations based on your health status, the severity of your symptoms, and your treatment goals. Always ensure that you have a thorough discussion about the potential risks and benefits of each approach before making a decision.

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