Endometrial Hyperplasia: Symptoms, Treatment, and When to Seek Help - Obstetrics and Gynecology

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Endometrial hyperplasia


In September, the doctor confirmed menopause through a blood test.
On December 15, menstruation returned with heavy flow, numerous blood clots, and prolonged duration.
After delaying until December 30, a vaginal ultrasound was performed, revealing endometrial hyperplasia.
The doctor prescribed a 7-day course of medications including Medroxyprogesterone Acetate, Clomiphene Citrate, and Diclofenac Sodium.
I inquired whether I should continue taking the medication if menstruation ceased, and after following the doctor's advice, I took the medication for three days before stopping it when menstruation stopped.
However, on January 5, menstruation returned.
Is this normal? I have scheduled a follow-up appointment in two months; do I need to see a doctor sooner?

amy, 40~49 year old female. Ask Date: 2014/01/05

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, if an ultrasound shows thickening of the endometrium, I generally recommend that my patients undergo a pathological examination of the endometrium before considering any medication.
Therefore, I suggest you consult your obstetrician-gynecologist or go to the hospital for further evaluation.
Wishing you good health.

Reply Date: 2014/01/05

More Info


Understanding endometrial hyperplasia is crucial for women, especially those who are approaching or have reached menopause. Endometrial hyperplasia refers to the thickening of the endometrium, the lining of the uterus, which can occur due to an imbalance in the levels of estrogen and progesterone. This condition can present with various symptoms, including heavy menstrual bleeding, prolonged periods, and the passage of blood clots, which you have described experiencing.

In your case, the onset of heavy bleeding with clots after a confirmed menopause indicates that there may be an underlying issue that needs to be addressed. While some degree of irregular bleeding can occur during the transition into menopause, significant changes such as heavy bleeding warrant further investigation. The ultrasound findings of endometrial hyperplasia suggest that the lining of your uterus is thicker than normal, which can be a response to prolonged estrogen exposure without adequate progesterone to counterbalance it.

The medications prescribed to you, including the hormonal treatments, are typically aimed at regulating the endometrial lining and reducing the risk of further hyperplasia or potential progression to more serious conditions, such as endometrial cancer. It is essential to follow your healthcare provider's instructions regarding medication adherence. If you stopped the medication after three days and experienced a return of your menstrual cycle, it may indicate that the treatment was not sufficient to stabilize your hormonal levels or that your body is still adjusting to the changes.

It is not uncommon for women to experience fluctuations in their menstrual cycles during this transitional phase, but the persistence of heavy bleeding and the presence of blood clots should not be ignored. You mentioned that you have a follow-up appointment scheduled in two months; however, given your recent symptoms, it would be prudent to consult your healthcare provider sooner. They may recommend additional diagnostic tests, such as an endometrial biopsy, to rule out any serious conditions and to assess the nature of the hyperplasia.

In summary, while some irregularities can be expected during menopause, the symptoms you are experiencing—heavy bleeding, prolonged periods, and blood clots—are concerning and should be evaluated promptly. It is essential to maintain open communication with your healthcare provider and to seek immediate care if your symptoms worsen or if you have any new concerns. Early intervention can help manage the condition effectively and reduce the risk of complications.

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