Can Medications Cause Menstrual Irregularities? the Impact - Obstetrics and Gynecology

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Can menstrual irregularities be caused by medication?


On Thursday, April 17th, I visited the clinic and was diagnosed with throat swelling caused by gastroesophageal reflux, which led to phlegm production.
The doctor prescribed the following medications: Erispan (Flupentixol), Voren 50 granules, Lyso 90 mg, Solaxin 200, and MOPRIDE (Mosapride).
I took them after each meal for two days, but on April 19th, I noticed a very small amount of brown discharge with some slight clots.
I initially thought it was my menstrual period, but by Monday, April 22nd, the discharge was still minimal, resembling the last day of a period.
My last menstrual cycle was from March 26th to March 31st, and I typically have a longer cycle, expecting my next period around April 29th.
I have no history of allergies, and I have only taken traditional Chinese medicine in the past.
This is the second time in two years that I have taken Western medicine.
Could this be a side effect of the medications?

zero zero, 20~29 year old female. Ask Date: 2014/04/22

Dr. Dong Yuhong reply Obstetrics and Gynecology


Hello: There are many factors that can affect menstruation.
In your case, it cannot be definitively attributed to Western medicine.
It is advisable to consult a gynecologist.
If examinations show no abnormalities in the uterus or ovaries, you can monitor your menstrual cycle for the next month.
If your period returns to normal, there is no need to worry too much.
Thank you!

Reply Date: 2014/04/22

More Info


Medications can indeed cause menstrual irregularities, and understanding the potential impact of the medications you are taking is crucial. In your case, you have been prescribed several medications, including Erispan (Flupine), Voren, Lyso, Solaxin, and MOPRIDE (Mosapride), for your condition related to gastroesophageal reflux disease (GERD) and throat swelling.
Firstly, it is important to recognize that various medications can affect hormonal balance and menstrual cycles in different ways. For instance, some medications may influence the hypothalamic-pituitary-ovarian axis, which regulates the menstrual cycle. Others may cause side effects that mimic premenstrual symptoms or alter the flow and timing of menstruation.

1. Erispan (Flupine): This medication is an antihistamine that can have sedative effects. While antihistamines are not typically associated with menstrual irregularities, they can cause drowsiness and other side effects that may indirectly affect your overall health and well-being.

2. Voren: This is a non-steroidal anti-inflammatory drug (NSAID) that can affect the menstrual cycle by altering prostaglandin levels. Prostaglandins are compounds that play a role in the regulation of the menstrual cycle and can influence menstrual flow. Some women may experience changes in their menstrual patterns when taking NSAIDs.

3. Lyso: This medication is often used for its mucolytic properties, helping to break down mucus. While it is not commonly linked to menstrual irregularities, any medication that affects your overall health can potentially have an indirect effect on your menstrual cycle.

4. Solaxin: This medication is a muscle relaxant that can help alleviate discomfort. While it is not directly linked to menstrual changes, any medication that alters your physical state can have an impact on your menstrual cycle.

5. MOPRIDE (Mosapride): This medication is a gastroprokinetic agent that enhances gastrointestinal motility. Similar to the other medications, it is not typically associated with menstrual irregularities, but it can affect your overall health and comfort.

Given that you experienced a change in your menstrual cycle shortly after starting these medications, it is plausible that the combination of these drugs, along with any stress or changes in your health status, could be contributing factors. The brown discharge you observed could be a sign of hormonal fluctuations or a response to the medications, especially if your cycle is usually regular.

It is also worth noting that stress, changes in diet, and lifestyle factors can significantly impact menstrual cycles. If you have recently experienced stress related to your health or any other life changes, this could also be a contributing factor to the irregularities you are observing.

In conclusion, while the medications you are taking may not directly cause menstrual irregularities, they can influence your overall health and hormonal balance, leading to changes in your menstrual cycle. If your symptoms persist or worsen, it is advisable to consult your healthcare provider. They can evaluate your situation more thoroughly, consider potential interactions between medications, and determine if any adjustments are necessary. Keeping a record of your menstrual cycle, including any changes in flow or symptoms, can also be helpful for your healthcare provider in assessing your condition.

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