Basophil Counts: What Do Your Blood Test Results Mean?

Eosinophilia typically indicates? (The first part was sent prematurely and is incomplete.)

Hello, Doctor.
I apologize for sending the previous message before I finished typing.
I would like to ask: The results of my health check-up at Taichung City Hospital at the end of 2012 showed the following: Neutrophil percentage 61.1% (reference range 41.7–73.7%), Lymphocyte percentage 27.3% (reference range 18.4–45.0%), Monocyte percentage 5.3% (reference range 4.6–12.3%), Eosinophil percentage 2.3% (reference range 0.7–8.1%), Basophil percentage 4.0% (reference range 0.2–1.4%).
The highlighted values were: Neutrophil count 4.0 (reference range 1.4–6.5 x 10^3/uL), Lymphocyte count 1.8 (reference range 1.2–3.4 x 10^3/uL), Monocyte count 0.3 (reference range 0.0–0.7 x 10^3/uL), Eosinophil count 0.2 (reference range 0.0–0.7 x 10^3/uL), Basophil count 0.3 (reference range 0.0–0.2 x 10^3/uL).
The highlighted white blood cell count was 6.6 (reference range 3.5–9.6 x 10^3/uL).
Later, at the beginning of this year, I had a blood test at a general laboratory, and the results were: Neutrophils 55% (reference range 50-70%), Lymphocytes 35% (reference range 20-40%), Monocytes 4% (reference range 2-6%), Eosinophils 2% (reference range 1-3%), Band neutrophils 3% (reference range 2-6%), Basophils 1% (reference range 0-1%), White blood cell count 8200/uL (reference range 5000-10000), Hemoglobin 31.37% (reference range 32-38%).
This value is highlighted.
Doctor, since my cousin passed away from leukemia, is it dangerous for me to have highlighted values? Is there a possibility of leukemia? Do I need to have regular check-ups? Additionally, I would like to ask, if I keep sneezing while pinching my nose and covering my mouth, could this cause a nosebleed or even lead to blood flowing back into my throat? (I have expelled a small blood clot.) Thank you, Doctor.
I appreciate it.

carol, 30~39 year old female. Ask Date: 2014/04/29

Dr. Xiao Yongxun reply Internal Medicine

1.
Regarding your white blood cell differential count, the total white blood cell count is normal, with a slightly elevated percentage of basophils and a slightly decreased hemoglobin level in red blood cells, which should be considered normal variations.
There is no evidence of blood cancer or leukemia; therefore, there is no need for concern.
As for the necessity of regular testing, other factors need to be considered, including age, comorbidities, findings from physical examinations, family history, and so on.
It is advisable to discuss this with your primary care physician before making a decision.
2.
There are many causes of nosebleeds, commonly associated with allergic rhinitis, hypertension, nasal infections, autoimmune diseases, medication effects, and individual habits, among others, including the situations you mentioned.
However, to rule out other possibilities, it is recommended that you visit an ear, nose, and throat specialist for an examination.

Reply Date: 2014/04/29

More Info

Understanding blood test results can be daunting, especially when certain values fall outside the normal range. In your case, you have expressed concerns regarding your basophil counts and other white blood cell (WBC) parameters, particularly in light of your family history of leukemia. Let's break down your results and address your concerns.

Basophils and White Blood Cell Counts
Basophils are a type of white blood cell that play a role in your immune response, particularly in allergic reactions and inflammation. Normal basophil counts typically range from 0.2% to 1.4% of total white blood cells. In your results, you noted a basophil percentage of 4.0%, which is significantly elevated. This could indicate an allergic reaction, chronic inflammation, or other underlying conditions. However, it is essential to interpret this value in conjunction with other parameters.

Your neutrophil percentage (61.1% and 55% in different tests) is within the normal range, while your lymphocyte percentage (27.3% and 35%) is also acceptable. The slight fluctuations in these values can be attributed to various factors, including stress, infections, or even recent vaccinations.

Total White Blood Cell Count
Your total white blood cell count of 6.6 (in one test) and 8200 (in another) is within the normal range (typically 4,500 to 11,000 cells per microliter). This suggests that, overall, your immune system is functioning adequately.

Concerns About Leukemia
Given your family history of leukemia, it is understandable to be concerned about your own blood test results. However, the presence of elevated basophils alone does not indicate leukemia. Leukemia is characterized by a significant increase in immature white blood cells (blasts) in the bloodstream, which is not reflected in your results. Additionally, the presence of normal neutrophil and lymphocyte counts further reduces the likelihood of a hematological malignancy.

Regular Monitoring
While your current results do not suggest an immediate risk of leukemia, it is wise to maintain regular check-ups, especially considering your family history. Regular monitoring can help detect any changes over time. If you notice any symptoms such as unexplained bruising, fatigue, or recurrent infections, you should consult your healthcare provider promptly.

Sneezing and Nosebleeds
Regarding your question about sneezing and the potential for nosebleeds, it is indeed possible to induce a nosebleed by forcefully sneezing, especially if you are pinching your nose. This action can create pressure in the nasal passages, leading to the rupture of small blood vessels. If you experience blood clots or bleeding that seems excessive or recurrent, it would be prudent to consult an ENT specialist.

Conclusion
In summary, while your basophil count is elevated, your overall white blood cell profile does not indicate leukemia. It is essential to keep an open line of communication with your healthcare provider, who can guide you on the necessity of further testing or monitoring. Regular check-ups and being aware of any new symptoms will be key in managing your health. If you have any further questions or concerns, do not hesitate to reach out to your physician.

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