Allegra: Addressing Fatigue and Allergic Asthma Treatment - Internal Medicine

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Allergy medications


Hello, Doctor Gao.
I have been using Allegra (60 mg) for allergic asthma for a long time, currently taking 0.5 tablets every night.
I have been on this medication for over a year.
During this time, I have noticed that I am always tired, waking up feeling like I need more sleep, and feeling fatigued throughout the day.
However, I read online that Allegra is a second-generation antihistamine and is supposed to have fewer side effects like drowsiness.
Still, I suspect that this medication makes me very sleepy (about half an hour after taking the medication, I feel compelled to go to bed).
However, I am hesitant to stop the medication, as my doctor mentioned that my dosage is quite low and should not cause drowsiness.
I would like to seek your professional opinion on this matter.
Thank you!

Hai Qiao, 40~49 year old female. Ask Date: 2014/05/19

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your message.
Allegra is indeed a new generation antihistamine, and a dosage of 60mg is quite low.
Taking half a tablet would likely result in a very small chance of drowsiness as a side effect.
However, individual responses can vary, and there are some unknown factors that may affect a person's sensitivity to antihistamines.
New generation antihistamines can still potentially cause drowsiness.
Therefore, my recommendations are: 1.
If you have tried multiple times and are certain that Allegra causes drowsiness, which affects your daytime work, it may be worth considering discontinuing the medication.
2.
If antihistamines are an important part of your treatment plan as advised by your physician, you might consider trying other new generation antihistamines.
The Allergy, Immunology, and Rheumatology Department at Changhua Hospital, Ministry of Health and Welfare, cares about your well-being.

Reply Date: 2014/05/19

More Info


Dear Patient,
Thank you for reaching out with your concerns regarding the use of Allegra (fexofenadine) for your allergic asthma and the fatigue you have been experiencing. It’s important to address both your medication and your symptoms comprehensively.

Allegra is indeed classified as a second-generation antihistamine, which is generally known for causing less sedation compared to first-generation antihistamines like diphenhydramine (Benadryl). However, individual responses to medications can vary significantly. While Allegra is less likely to cause drowsiness, some patients may still experience fatigue or sleepiness as a side effect, even at lower doses. This could be due to several factors, including your body’s unique chemistry, the presence of other medications, or underlying health conditions.

Chronic fatigue can also be influenced by various factors unrelated to your medication. For instance, allergic asthma itself can lead to poor sleep quality due to nighttime symptoms such as coughing, wheezing, or shortness of breath. If your asthma is not well-controlled, it could contribute to feelings of fatigue during the day. Additionally, other factors such as stress, diet, sleep hygiene, and even depression can play significant roles in how rested you feel.

Given that you have been on Allegra for over a year, it might be beneficial to evaluate your asthma management plan. If you are experiencing persistent symptoms, it may be time to discuss with your healthcare provider the possibility of adjusting your asthma medications or exploring additional treatments. This could include inhaled corticosteroids or other long-term control medications that may help improve your overall asthma control and, consequently, your sleep quality.

If you suspect that Allegra is contributing to your fatigue, you might consider discussing alternative antihistamines with your doctor. Options such as loratadine (Claritin) or cetirizine (Zyrtec) may be worth exploring, as they have different side effect profiles. However, any changes to your medication regimen should be done under the guidance of your healthcare provider to ensure that your allergic asthma remains well-managed.

In the meantime, here are some strategies to help improve your energy levels and overall well-being:
1. Sleep Hygiene: Establish a regular sleep schedule, create a comfortable sleep environment, and limit screen time before bed to improve sleep quality.

2. Asthma Management: Ensure that your asthma is well-controlled. Regular follow-ups with your healthcare provider can help adjust your treatment plan as needed.

3. Physical Activity: Engage in regular, moderate exercise, which can help boost energy levels and improve sleep quality.

4. Diet: Maintain a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. Staying hydrated is also essential.

5. Stress Management: Consider relaxation techniques such as mindfulness, yoga, or meditation to help manage stress, which can impact both sleep and fatigue.

6. Consultation: If fatigue persists despite these measures, it may be worthwhile to consult with a specialist, such as a sleep medicine physician or a pulmonologist, to rule out other underlying conditions.

In conclusion, while Allegra is less likely to cause drowsiness, individual reactions can vary. It’s crucial to have an open dialogue with your healthcare provider about your symptoms, medication, and overall asthma management. Together, you can find the best approach to improve your quality of life while effectively managing your allergic asthma.

Best wishes for your health and well-being.

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