Seizures: Why EEG Results Can Be Normal Despite Symptoms - Neurology

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Epilepsy cannot be diagnosed?


Hello, doctor! I have fainted before and hit my head, but since April, I have been experiencing episodes two to three times a week where I lose consciousness and don't remember anything, even in the hospital.
I feel extremely fatigued.
I have visited many hospitals, and my EEG results have all been normal.
The doctors asked me if I was under any stress, and I told them I wasn't.
The psychiatrist also said that I have no stress and everything is normal.
The psychiatrist mentioned that there might be something else going on.
I would like to ask the doctor if EEGs can sometimes show abnormalities and sometimes not (I am currently on medication to manage my condition).

En En, 10~19 year old female. Ask Date: 2014/07/11

Dr. Gao Chunde reply Neurology


The rate of capturing epileptic waves in a single EEG is approximately 50%.
When combined with awake and sleep EEG patterns, conducting four tests yields about 80% detection of abnormalities.
Therefore, it is essential to correlate with clinical findings.
If necessary, further methods such as continuous EEG monitoring or nasopharyngeal electrode EEG can increase the positive detection rate (though not every hospital has these capabilities).

Reply Date: 2014/07/11

More Info


Understanding seizures and their relationship with EEG (electroencephalogram) results can be quite complex. It's important to recognize that while EEG is a valuable tool for diagnosing seizure disorders, it does not always provide a definitive answer, especially in cases where a patient exhibits seizure-like symptoms but has normal EEG results.

Seizures are caused by abnormal electrical activity in the brain. When a patient experiences a seizure, the brain's electrical activity can become chaotic, leading to various symptoms such as loss of consciousness, convulsions, or unusual sensations. An EEG measures this electrical activity and can help identify patterns associated with seizures. However, there are several reasons why an EEG might appear normal even when a patient is experiencing seizures.

1. Interictal vs. Ictal Activity: The EEG can be normal during the interictal period (the time between seizures). If the EEG is performed when the patient is not actively seizing, it may not capture the abnormal brain activity that occurs during a seizure. This is why some patients may require prolonged EEG monitoring or video EEG to capture the electrical activity during a seizure.

2. Types of Seizures: Different types of seizures may produce different EEG patterns. For instance, focal seizures may not show generalized changes on an EEG, especially if they originate from a small area of the brain. In such cases, the EEG may appear normal if the seizure activity is localized and not widespread.

3. Subclinical Seizures: Some seizures may not produce noticeable physical symptoms but can still be detected on an EEG. These are known as subclinical seizures. Conversely, a patient may experience episodes that resemble seizures but are not due to abnormal electrical activity in the brain, such as psychogenic non-epileptic seizures (PNES).

4. Medication Effects: If a patient is on anti-seizure medications, these can influence the EEG results. Medications may suppress seizure activity, leading to a normal EEG even if the patient has a history of seizures.

5. Stress and Psychological Factors: While you mentioned that both you and your psychiatrist do not perceive stress as a contributing factor, psychological stress can sometimes manifest in physical symptoms that mimic seizures. This can lead to confusion in diagnosis, particularly if the EEG does not show any abnormalities.

Given your situation, where you have experienced multiple episodes of losing consciousness and have undergone several EEG tests with normal results, it is crucial to continue working closely with your healthcare providers. They may consider additional diagnostic approaches, such as:
- Prolonged EEG Monitoring: This can help capture any seizure activity that occurs over an extended period.

- Neuroimaging: MRI or CT scans can help identify structural abnormalities in the brain that may contribute to seizure activity.

- Comprehensive Evaluation: A thorough assessment of your medical history, including any potential triggers for your episodes, can provide valuable insights.

In conclusion, while normal EEG results can be frustrating, they do not rule out the possibility of seizures or seizure-like episodes. It is essential to maintain open communication with your healthcare team and explore further diagnostic options to ensure you receive the appropriate treatment and support. If you continue to experience symptoms, do not hesitate to seek further evaluation or a second opinion from a neurologist specializing in seizure disorders.

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