Pancreatic Variations: Concerns and Next Steps After Diagnosis - Gastroenterology and Hepatology

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Please provide more details regarding the pancreatic issues you are experiencing?


Hello, Dr.
Lin.
A month ago, when I returned to Taiwan and underwent a comprehensive health check at Asia University Hospital, an abdominal ultrasound revealed a hyperechoic nodule approximately 1 cm in size in the head of the pancreas.
Subsequently, the doctor performed a contrast-enhanced abdominal CT scan (with contrast agent) and ordered blood tests for CA19-9 and CEA.
The CT report indicated that the size, density, and enhancement of the pancreas were normal, but there was a protrusion in front of the head of the pancreas measuring 2.5 x 1 cm, which also showed normal enhancement.
The doctor mentioned that there was no tumor in the pancreas and that it might be a variant.
Additionally, both CA19-9 and CEA levels were normal.

Next, I underwent an endoscopic ultrasound (EUS), which indicated no lesions in the head, body, or tail of the pancreas, and there was no dilation of the pancreatic duct.
The EUS report also showed no abnormal findings.
Despite undergoing numerous tests, the doctor did not provide me with a detailed explanation; instead, I was given a pile of reports and told to follow up in three months.
This has left me with many questions, and I often wonder if congenital variations of the pancreas are common.
My grandmother passed away from pancreatic cancer two months ago, which has filled me with fear regarding this organ.

My questions are: Are congenital variations of the pancreas common? Why was there no detection during the abdominal ultrasound two years ago when a CT scan was not performed, and why was it only discovered a month ago? Could this have developed in the past two years? Do I need to undergo further MRI imaging? I am unsure of what to do.
Thank you very much!

Mr. Li, 30~39 year old female. Ask Date: 2015/01/30

Dr. Lin Minghui reply Gastroenterology and Hepatology


Hello: Congenital variations of the pancreas are not common and are difficult to examine.
Some are discovered only after an unexplained episode of pancreatitis.
The most sensitive examination for pancreatic tumors is endoscopic ultrasound (EUS), which can detect tumors smaller than 1 cm, and aspiration cytology can be performed if necessary.
Both MRI and CT are imaging studies.
Magnetic resonance cholangiopancreatography (MRCP) may be more effective than CT in identifying lesions within the bile ducts and pancreatic duct.
This information is for reference only, and it is still recommended to discuss with a physician in clinical practice.
Wishing you safety and health.
Sincerely, Dr.
Lin Ming-Hui, Department of Gastroenterology, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2015/01/30

More Info


It's understandable to feel anxious after receiving a diagnosis that involves the pancreas, especially given your family history of pancreatic cancer. Let's break down your situation and address your concerns regarding pancreatic variations, the significance of your recent imaging studies, and the next steps you should consider.


Understanding Pancreatic Variations
Pancreatic variations, such as anatomical anomalies or benign lesions, are not uncommon. The pancreas can exhibit a range of normal anatomical variations that may appear as nodules or masses on imaging studies. These variations can include accessory pancreatic tissue, pancreatic divisum, or even benign cysts. The fact that your imaging studies have indicated no lesions or abnormalities in the pancreas, along with normal levels of tumor markers (CA19-9 and CEA), is reassuring.


Recent Imaging and Findings
You mentioned that an ultrasound detected a hyperechoic nodule in the head of the pancreas, which was further evaluated with a contrast-enhanced CT scan and endoscopic ultrasound (EUS). The CT scan showed that the pancreas appeared normal in size and density, with a noted protrusion in the head of the pancreas that was likely a variation rather than a tumor. The EUS corroborated these findings, indicating no lesions or ductal dilation.

The absence of significant findings on multiple imaging modalities suggests that the nodule is likely benign. It's important to note that imaging techniques can sometimes yield different results based on the timing and the specific characteristics of the pancreas at the time of the examination. Changes in the pancreas can occur over time, and it is possible that the nodule was not present or not detectable during your previous ultrasound two years ago.


Next Steps and Recommendations
Given your situation, here are some recommendations:
1. Follow-Up Imaging: Your physician has suggested a follow-up in three months, which is a standard practice for monitoring any changes in pancreatic findings. This is a prudent approach, especially since your recent imaging has not shown any concerning features.

2. Further Evaluation: If you continue to have concerns or if your symptoms change, discussing the possibility of an MRI with your healthcare provider may be beneficial. An MRI can provide additional detail about soft tissue structures and may help clarify any uncertainties regarding the pancreatic nodule.

3. Consultation with a Specialist: If you feel that your concerns are not being adequately addressed, consider seeking a second opinion from a gastroenterologist or a pancreatic specialist. They can provide more insight into your specific case and help alleviate your fears.

4. Family History Consideration: Given your grandmother's history of pancreatic cancer, it is understandable to be vigilant about your own pancreatic health. While familial factors can increase the risk of certain conditions, the absence of concerning findings in your imaging studies is a positive sign.

5. Lifestyle and Monitoring: Maintain a healthy lifestyle, including a balanced diet and regular exercise, which can support overall pancreatic health. Additionally, keep track of any symptoms you may experience and report them to your healthcare provider.


Conclusion
In summary, while pancreatic variations can occur, the findings from your recent imaging studies suggest that there is no immediate cause for concern. Regular follow-up and monitoring are essential, and if you have ongoing worries, do not hesitate to seek further evaluation. Your health and peace of mind are paramount, and staying informed about your condition is an important part of managing your health.

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