Chronic Kidney Disease Stage 1
Hello, doctor...
I have had mild proteinuria since high school.
During a company health check, the urine test showed proteinuria intermittently (+/-).
About six years ago, I underwent a 24-hour urine test, and the results were within the normal range.
My creatinine levels have always been normal, but I recently learned that it can be converted to "glomerular filtration rate" (GFR).
I found out that for at least the past ten years, I have actually been in stage 1 chronic kidney disease, fortunately without any deterioration (normal kidney function but with proteinuria, hematuria, and other signs of kidney damage, with kidney function at about 60% of that of a healthy individual).
Additionally, my sleep study revealed central sleep apnea, and I often feel fatigued, but I do not have any edema.
I would like to ask if stage 1 chronic kidney disease can cause central sleep apnea and excessive fatigue?
Y, 40~49 year old female. Ask Date: 2015/02/25
Dr. Wu Jiyu reply Internal Medicine
1.
Chronic Kidney Disease Stage 1 is defined as a glomerular filtration rate (GFR) of 90 mL/min/1.73 m² or higher, accompanied by proteinuria, hematuria, or abnormal kidney morphology.
Based on your description of "24-hour urine test results within normal range," this does not meet the definition.
2.
To further confirm proteinuria, a spot urine sample can be collected to calculate the protein-to-creatinine ratio.
If the ratio is less than 150 mg/g, it is considered normal.
3.
If there are symptoms of obstructive sleep apnea, this may lead to fatigue.
It is recommended to consult a pulmonologist for diagnosis.
Thank you for your inquiry; the Nephrology Department at Changhua Hospital cares about your health.
Reply Date: 2015/02/25
More Info
Understanding Stage 1 Chronic Kidney Disease (CKD) is crucial for managing your health effectively. In your case, it appears that you have been diagnosed with Stage 1 CKD, which is characterized by a glomerular filtration rate (GFR) of 90 mL/min/1.73 m² or higher, along with the presence of proteinuria or hematuria. It’s important to note that while your kidney function appears to be stable, the presence of protein in your urine indicates that there may be some underlying kidney damage.
Symptoms and Concerns
1. Proteinuria and Hematuria: The presence of protein (proteinuria) and blood (hematuria) in your urine can be indicative of kidney damage. While you mentioned that your 24-hour urine tests have been normal, it’s essential to monitor these parameters regularly. Proteinuria can fluctuate, and it may be beneficial to conduct a spot urine test to measure the protein-to-creatinine ratio for a more accurate assessment.
2. Fatigue and Sleep Issues: You mentioned experiencing significant fatigue and central sleep apnea. While Stage 1 CKD itself may not directly cause these symptoms, there are several interrelated factors to consider:
- Sleep Apnea: Central sleep apnea can lead to disrupted sleep patterns, which may contribute to feelings of fatigue during the day. Poor sleep quality can exacerbate feelings of tiredness and lethargy.
- Kidney Function and Fatigue: Although your kidney function is currently stable, chronic kidney disease can lead to anemia over time, which is characterized by low red blood cell counts. Anemia can cause fatigue and weakness. Regular blood tests to monitor hemoglobin levels are advisable.
- Lifestyle Factors: Factors such as diet, hydration, and physical activity can also influence your energy levels. A balanced diet that supports kidney health is essential, and staying hydrated is crucial, but be mindful of your fluid intake if you have any restrictions.
3. Monitoring and Management: Given your history of proteinuria and the current diagnosis of Stage 1 CKD, it is vital to maintain regular follow-ups with your healthcare provider. They may recommend:
- Regular Kidney Function Tests: Monitoring your GFR and urine protein levels periodically to track any changes.
- Blood Pressure Management: High blood pressure can worsen kidney function, so it’s essential to keep it within a healthy range.
- Dietary Adjustments: A diet low in sodium and rich in fruits, vegetables, and whole grains can be beneficial for kidney health. However, since you have a history of mitral valve prolapse and related heart issues, it’s crucial to balance your sodium intake as advised by your cardiologist.
4. Consulting Specialists: If you continue to experience fatigue and sleep disturbances, it may be beneficial to consult with a sleep specialist for a comprehensive evaluation of your sleep apnea. Additionally, a nephrologist can provide tailored advice regarding your kidney health and any necessary lifestyle modifications.
Conclusion
In summary, while Stage 1 CKD may not directly cause symptoms like fatigue or sleep apnea, the interplay of kidney function, sleep quality, and overall health can contribute to your experiences. Regular monitoring, lifestyle adjustments, and consultations with healthcare professionals are key to managing your condition effectively. It’s essential to stay proactive about your health and communicate any changes or concerns with your healthcare team.
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