Ultrasound Shows Embryo but Pregnancy Test Says Negative: What's Happening? - Obstetrics and Gynecology

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An embryo is visible, but pregnancy cannot be detected?


I had my last menstrual period on March 28, with a cycle length of approximately 32 days.
On May 5, I went to the hospital for a transvaginal ultrasound, where an embryo was detected, but my urine pregnancy test came back negative.
That day, the doctor administered a medication to induce menstruation.
Today is May 8, and my period still hasn't arrived.
The doctor mentioned that this situation is contradictory, as typically, if an embryo is seen on the ultrasound, the pregnancy test would also be positive, but in my case, it is the opposite.
Am I pregnant? Thank you.

S, 30~39 year old female. Ask Date: 2015/05/08

Dr. Cao Guotao reply Obstetrics and Gynecology


Please visit the outpatient clinic for further examination.
Wishing you good health.

Reply Date: 2015/05/08

More Info


The situation you are describing is indeed perplexing and can be quite concerning for anyone experiencing it. When an ultrasound shows an embryo but a pregnancy test returns negative, it raises several questions about the nature of the pregnancy and the accuracy of the tests being used.

Firstly, let's clarify how pregnancy tests work. Most home pregnancy tests detect the hormone human chorionic gonadotropin (hCG), which is produced shortly after a fertilized egg attaches to the uterine lining. Typically, hCG levels can be detected in urine about 14 days after conception. However, there are several factors that can lead to a negative test result even when a pregnancy is present.

1. Timing of the Test: If the test is taken too early, hCG levels may not be high enough to be detected. This is especially relevant if your menstrual cycle is irregular or longer than average, as ovulation may have occurred later than expected.

2. Chemical Pregnancy: This is a very early miscarriage that can occur shortly after implantation. In such cases, hCG may be present for a short time but then drop, leading to a negative test result even if an embryo was initially detected on ultrasound.

3. Ectopic Pregnancy: In some cases, an embryo may implant outside the uterus, such as in a fallopian tube. This can sometimes be detected on ultrasound, but hCG levels may not rise as expected, leading to negative urine tests.

4. Ultrasound Limitations: Ultrasound can sometimes detect an embryo earlier than hCG can be detected in urine. This is particularly true in cases of very early pregnancy or when the embryo is not developing normally.

5. False Negative Tests: Home pregnancy tests are not infallible. Factors such as expired tests, improper usage, or diluted urine can lead to false negatives.

Given your situation, where an ultrasound has confirmed the presence of an embryo but urine tests are negative, it is crucial to follow up with your healthcare provider. They may recommend a blood test to measure the exact levels of hCG in your bloodstream, which can provide more definitive information about your pregnancy status. Blood tests are more sensitive than urine tests and can detect lower levels of hCG.

Additionally, since you mentioned receiving a medication to induce menstruation, it is essential to understand how this may affect your body. If the medication is effective, it could lead to a menstrual period, which would indicate that the pregnancy is not viable. However, if the embryo is still present, it may complicate matters further.

In summary, while it is possible to have an ultrasound show an embryo and a negative pregnancy test, it is essential to conduct further testing and monitoring. Your healthcare provider will be able to give you the best guidance based on your specific circumstances. It is also important to keep track of any symptoms you may experience, such as abdominal pain or unusual bleeding, and report these to your doctor promptly.
Ultimately, the best course of action is to maintain open communication with your healthcare provider, who can help you navigate this confusing situation and determine the next steps based on your health and the findings from your tests.

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