Hepatitis B Antibodies: Vaccine Response and Risks - Gastroenterology and Hepatology

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Hello! Thank you for your question regarding Hepatitis B vaccination and antibody response. It’s important to understand the implications of your vaccination history and the absence of antibodies in your case.

From what you’ve described, it appears that you received the Hepatitis B vaccine during childhood but did not develop protective antibodies (Anti-HBs) in subsequent tests. This situation can occur for a few reasons. Some individuals may not respond adequately to the vaccine due to various factors, including age, underlying health conditions, or immune system responses. The fact that you have received a booster dose and still did not develop antibodies suggests that you might be a non-responder to the vaccine.

In general, the Hepatitis B vaccine is highly effective, with about 90% of healthy adults developing protective antibodies after completing the vaccination series. However, a small percentage of individuals may not respond adequately. For those who do not develop antibodies after the primary series and a booster, it is recommended to consult with a healthcare provider for further evaluation. This might include checking for any underlying conditions that could affect immune response, such as chronic liver disease or immunosuppressive conditions.

Regarding your concern about the risk of Hepatitis B infection, it is important to note that without protective antibodies, you are at risk of contracting the virus if exposed. Hepatitis B is primarily transmitted through contact with infectious body fluids, such as blood, semen, or vaginal secretions. This means that if you were to come into contact with the blood of an infected person, there is a risk of transmission.

Given your history of elevated liver enzymes and fatty liver disease, it is crucial to monitor your liver health closely. While your recent tests have ruled out Hepatitis B and C infections, it is advisable to continue regular check-ups with your healthcare provider. They may recommend additional vaccinations or alternative preventive measures, especially if you are at risk of exposure.

If you are considering revaccination, it may be beneficial to discuss this with your healthcare provider. They may suggest a different vaccination schedule or even the use of a different vaccine formulation. In some cases, if a person is a non-responder, healthcare providers may recommend additional doses or alternative strategies to ensure protection against Hepatitis B.

In summary, since you have not developed antibodies after vaccination, you remain at risk for Hepatitis B infection. It is advisable to consult with your healthcare provider about the possibility of revaccination and to discuss any underlying health issues that might affect your immune response. Regular monitoring of your liver function and overall health is essential, especially given your history of elevated liver enzymes. Stay proactive about your health, and don’t hesitate to seek further medical advice tailored to your specific situation.