Blisters After Cryotherapy for Viral Warts: What to Expect - Dermatology

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Blister formation after cryotherapy for viral warts?


A week ago, I underwent cryotherapy, and about two days later, blisters formed.
However, in addition to the treated area, the surrounding skin also became swollen, and it has developed into a lump.
Is this normal? How long will it take for the scab to form? Sometimes it feels itchy; what could be the reason for that? If I touch it, it feels tingly; is this normal?

Yáo wǔ, 20~29 year old female. Ask Date: 2015/07/18

Dr. Li Yufen reply Dermatology


Hello: Cryotherapy involves extremely low temperatures, which may lead to the formation of blisters around the treated lesion.
After a few days, these blisters may turn dark purple or black.
The time it takes for scabbing to occur varies significantly depending on the size of the blister and individual healing factors.
If the blister is large and affects daily activities, it is advisable to return for a follow-up appointment to have the blister drained.
If it is manageable, you can wait for it to gradually scab and fall off.
If any residual viral warts remain after the scab falls off, further cryotherapy can be performed.
Thank you!

Reply Date: 2015/07/18

More Info


Cryotherapy is a common treatment for viral warts, utilizing extreme cold to destroy abnormal tissue. After undergoing this procedure, it's not uncommon to experience a range of reactions, including the formation of blisters. Understanding what to expect post-treatment can help alleviate concerns and guide proper care.

Blister Formation: The appearance of blisters within a couple of days after cryotherapy is a typical response. The freezing process causes damage to the wart tissue, and the body reacts by creating a blister as part of the healing process. This blister serves as a protective barrier, allowing the underlying skin to heal without exposure to external irritants or pathogens.

Swelling and Surrounding Area: It's also not unusual for the area surrounding the treated wart to swell. This can occur due to inflammation as the body responds to the trauma inflicted by the cryotherapy. The swelling may appear as a lump and can be accompanied by redness and tenderness. If the swelling is significant or accompanied by severe pain, it’s advisable to consult your healthcare provider to rule out any complications.

Itching Sensation: The itching you are experiencing is a common symptom during the healing process. Itching can occur as the skin begins to regenerate and can be a sign of healing. However, it’s essential to avoid scratching the area, as this can lead to further irritation or even infection.

Numbness or Tingling: The "tingling" or "pins and needles" sensation you describe when touching the area is also a normal reaction. This sensation can result from nerve endings being affected by the freezing process. As the skin heals, these sensations should gradually subside.

Scabbing Timeline: Typically, the blister will eventually dry out and form a scab. This process can take anywhere from a few days to a couple of weeks, depending on the individual’s healing response and the size of the treated area. It’s crucial to keep the area clean and dry to promote healing and prevent infection. If the blister breaks, it’s essential to cover it with a sterile bandage and keep an eye on it for any signs of infection, such as increased redness, warmth, or pus.

When to Seek Help: While many reactions to cryotherapy are normal, certain signs warrant a visit to your healthcare provider. If you notice excessive swelling, persistent pain, signs of infection, or if the blister does not heal within a reasonable timeframe, it’s important to seek medical advice. Your healthcare provider can assess the situation and provide appropriate treatment if necessary.

In summary, the reactions you are experiencing after cryotherapy for viral warts, including blister formation, swelling, itching, and tingling sensations, are generally normal. These symptoms indicate that your body is responding to the treatment and working to heal the area. However, maintaining proper care and monitoring for any unusual changes is essential to ensure a smooth recovery. If you have any concerns, don’t hesitate to reach out to your healthcare provider for guidance.

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