Is it Mediterranean anemia?
Hemoglobin 11.5, hematocrit 34.7, MCV 69.9, MCH 23.2, MCHC 33.1, RDW 16.3, lymphocytes 15.10.
Based on these values, does this indicate thalassemia?
joi, 20~29 year old female. Ask Date: 2015/07/26
Dr. He Dongjin reply Cardiology
Hello, based on your report, it appears to be more like iron deficiency anemia.
It is recommended to visit the hematology department for further tests on iron levels and red blood cells.
Changhua Hospital cares about you.
Reply Date: 2015/07/26
More Info
To determine whether you might have Mediterranean anemia, also known as thalassemia, we need to analyze your blood test results in detail. Based on the values you've provided, let's break down the key components and their implications.
1. Hemoglobin (Hb): Your hemoglobin level is 11.5 g/dL. Normal hemoglobin levels typically range from about 12 to 16 g/dL for women and 13.5 to 17.5 g/dL for men. A level of 11.5 g/dL indicates mild anemia, which could be due to various causes, including iron deficiency, chronic disease, or thalassemia.
2. Hematocrit (HCT): Your hematocrit is 34.7%. Normal ranges are approximately 36% to 46% for women and 41% to 50% for men. This value also suggests anemia since it is below the normal range.
3. Mean Corpuscular Volume (MCV): Your MCV is 69.9 fL. Normal MCV values range from 80 to 100 fL. A low MCV indicates microcytic anemia, which is often seen in iron deficiency anemia and thalassemia.
4. Mean Corpuscular Hemoglobin (MCH): Your MCH is 23.2 pg. Normal values are typically between 27 to 31 pg. A low MCH further supports the diagnosis of microcytic anemia.
5. Mean Corpuscular Hemoglobin Concentration (MCHC): Your MCHC is 33.1 g/dL, which falls within the normal range (32 to 36 g/dL). This suggests that the concentration of hemoglobin in your red blood cells is adequate, but the cells themselves are smaller than normal.
6. Red Cell Distribution Width (RDW): Your RDW is 16.3%. Normal RDW values are usually between 11.5% and 14.5%. An elevated RDW indicates a variation in red blood cell size, which can be seen in various types of anemia, including thalassemia.
7. Lymphocyte Count: You mentioned a lymphocyte count of 15.10, but the unit is unclear. If this is in thousands per microliter (K/µL), it would be considered high, which could indicate a response to infection or other conditions.
Conclusion
Based on your results, particularly the low hemoglobin, low MCV, and low MCH, there is a possibility of microcytic anemia, which could be due to iron deficiency or thalassemia. Thalassemia is characterized by a genetic defect that affects hemoglobin production, leading to microcytic anemia.
To further investigate whether you have Mediterranean anemia (thalassemia), additional tests are typically required, including:
- Iron Studies: To check your iron levels, ferritin, and total iron-binding capacity (TIBC) to rule out iron deficiency anemia.
- Hemoglobin Electrophoresis: This test can help identify different types of hemoglobin and is crucial in diagnosing thalassemia.
- Family History: Since thalassemia is hereditary, knowing your family history can provide valuable context.
Recommendations
1. Consult a Hematologist: Given your blood test results, it would be beneficial to consult a hematologist who can provide a comprehensive evaluation and recommend further testing.
2. Monitor Symptoms: Pay attention to any symptoms such as fatigue, weakness, or pallor, which could indicate worsening anemia.
3. Dietary Considerations: If iron deficiency is suspected, consider dietary changes to include iron-rich foods (like red meat, beans, and leafy greens) and vitamin C to enhance iron absorption.
In summary, while your results suggest the possibility of microcytic anemia, further testing is essential to determine if it is due to thalassemia or another cause.
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