Yellow Breast Discharge: Causes and Treatment Insights

Unilateral breast yellow discharge?

Dear Dr.
Chou,
I would like to ask you about my family member who is 33 years old and has not yet become pregnant.
Recently, we discovered that she has a large uterine fibroid.
She has been undergoing treatment for two months, initially taking Urokinase and now receiving Leuprolide for treatment.
Previously, she did not notice any breast discharge, but after starting treatment, she has observed yellow discharge from one breast that dries and forms small clumps.
When we inquired with the treating physician, he mentioned that this is not a known side effect, although breast swelling, atrophy, and varying sizes can occur as side effects.
I have two questions for you, Dr.
Chou:
1.
Could this situation be caused by the treatments mentioned above?
2.
The yellow discharge occurs intermittently from the same area.
Aside from the effects of the treatment, what other reasons or conditions could potentially cause this?
Thank you for your time, Dr.
Chou.

Xiao Xiao, 30~39 year old female. Ask Date: 2015/08/19

Dr. Zhou Jiazhen reply Breast and Thyroid

Dear Xiao Xiao,
Hello,
1.
Lurasidone is a central nervous system depressant that can cause side effects similar to those of menopause syndrome, such as hot flashes, palpitations, irritability, and insomnia.

2.
Breast discharge is related to hormonal changes in the mammary ducts.
If the discharge occurs in the same area, it is likely a simple issue with the mammary ducts.
However, lurasidone should not cause this phenomenon; whether it is due to hormonal changes after use remains uncertain.
If the aforementioned symptoms persist, a consultation at the outpatient clinic is recommended.

Wishing you peace, health, and well-being.
Sincerely,
Zhou Jiazhen
Director of Surgery, Taoyuan Hospital, Ministry of Health and Welfare

Reply Date: 2015/08/19

More Info

Understanding yellow breast discharge can be quite complex, as it can arise from various underlying causes, particularly in the context of hormonal treatments and breast health. In your case, the yellow discharge from one breast, especially after starting treatment for uterine fibroids, raises several important considerations.

Firstly, the treatment you mentioned, particularly the use of medications like "佑汝" (likely a hormonal therapy) and "柳培林" (which is a central nervous system inhibitor), can indeed influence breast tissue and discharge. Hormonal fluctuations can lead to changes in the breast ducts, resulting in discharge that may be yellow or even sticky. This is often due to the accumulation of fluid in the ducts, which can occur when hormonal levels fluctuate or when there is a response to medication.
1. Is the yellow discharge related to the treatment?
While your doctor indicated that yellow discharge is not a common side effect of the medications, it is essential to recognize that hormonal therapies can lead to various changes in breast tissue. The discharge you are experiencing could be a result of hormonal changes induced by the treatment. It is not uncommon for women undergoing hormonal therapy to experience changes in breast discharge, including the appearance of fluid that can be yellowish in color.
2. What other causes could explain the yellow discharge?
Besides hormonal influences, there are several other potential causes for unilateral yellow discharge from the breast:
- Infection or Inflammation: Conditions such as mastitis or a localized infection can lead to discharge that may be yellow or greenish. This is often accompanied by other symptoms like redness, swelling, or pain.

- Ductal Ectasia: This condition occurs when a milk duct beneath the nipple dilates, fills with fluid, and thickens, which can lead to discharge that may be yellow or sticky.

- Benign Growths: Sometimes, benign conditions such as intraductal papillomas can cause discharge. These are non-cancerous growths in the ducts that can lead to fluid production.

- Breast Cysts: Fluid-filled sacs in the breast tissue can also lead to discharge, especially if they are located near the ducts.

Given the complexity of breast health and the potential implications of your symptoms, it is crucial to seek further evaluation. A breast specialist can perform a thorough examination, possibly including imaging studies like a mammogram or ultrasound, to assess the breast tissue and identify any underlying issues. If necessary, they may recommend further tests, such as a ductogram or even a biopsy, to rule out more serious conditions.

In conclusion, while hormonal treatment may play a significant role in the changes you are observing, it is essential to consider other potential causes of yellow breast discharge. Monitoring your symptoms and consulting with a healthcare provider who specializes in breast health will be vital in ensuring that any underlying issues are addressed appropriately. Regular follow-ups and open communication with your healthcare team will help manage your health effectively during this treatment period.

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