Heart Medications: Concerns for Mitral Valve Prolapse and Autonomic Dysfunction

Q: Heart Medications: Concerns for Mitral Valve Prolapse and Autonomic Dysfunction

Hello Miss Wenwen： 1. Mitral valve prolapse is currently explained in medicine as related to autonomic nervous system dysregulation. 2. Bisoprolol (Concor), approved by the Ministry of Health and Welfare, is indicated for hypertension, angina pectoris, and sta

Cardiac medications

I have mild mitral valve prolapse and symptoms of autonomic nervous system dysfunction.
I have been taking Kankin 1.25 for one month.
I measured my blood pressure once, and it was 127.
The medication packaging states that it is indicated for stable chronic moderate to severe heart failure.
I am unsure what this definition means, as I have found many resources indicating that this medication is typically prescribed for significant heart issues.
Are there any specific medications that should not be taken together with this one? I am currently also taking antihistamines.

Wenwen, 10~19 year old female. Ask Date: 2015/09/25

Dr. Xie Weigong reply Pharmacology

Hello Miss Wenwen:
1.
Mitral valve prolapse is currently explained in medicine as related to autonomic nervous system dysregulation.

2.
Bisoprolol (Concor), approved by the Ministry of Health and Welfare, is indicated for hypertension, angina pectoris, and stable chronic moderate to severe heart failure.
It is generally taken in the morning on an empty stomach or with breakfast, swallowed whole with water.
However, if there is hypotension, the medication should be discontinued immediately.
Your condition is not heart failure, so there is no need to worry.

3.
The treatment for mitral valve prolapse typically involves beta-blockers or the combination with anxiolytic medications, which can improve most symptoms, and Bisoprolol (Concor) is a type of beta-blocker.

4.
It is not recommended to combine it with calcium channel blockers (a type of antihypertensive medication).

Wishing you good health,
Pharmacist Hsieh Wei-Kung

Reply Date: 2015/09/25

More Info

Mitral valve prolapse (MVP) is a condition where the mitral valve does not close properly, which can lead to mitral regurgitation and other complications. It is often benign but can be associated with symptoms such as palpitations, anxiety, and autonomic dysfunction. Autonomic dysfunction refers to an imbalance in the autonomic nervous system, which controls involuntary bodily functions, including heart rate and blood pressure regulation.
In your case, you mentioned that you have mild mitral valve prolapse and autonomic dysfunction, and you are currently taking Concor (bisoprolol), which is a beta-blocker. Beta-blockers are commonly prescribed for various cardiovascular conditions, including hypertension, heart failure, and arrhythmias. They work by blocking the effects of adrenaline on the heart, leading to a decrease in heart rate and blood pressure, which can help alleviate symptoms associated with MVP and autonomic dysfunction.

The indication for Concor that you mentioned—"stable chronic moderate to severe heart failure"—is indeed a more serious condition. However, beta-blockers are also used in patients with milder forms of heart disease or those who experience symptoms like palpitations or anxiety related to MVP. The use of this medication in your case may be aimed at managing symptoms rather than treating severe heart failure.

When taking Concor, it is essential to monitor your blood pressure and heart rate regularly, as beta-blockers can lower both. You noted that your highest recorded blood pressure was 127 mmHg, which is within the normal range. However, it is crucial to ensure that your blood pressure does not drop too low, especially if you experience dizziness or lightheadedness.

Regarding drug interactions, beta-blockers can interact with various medications. It is particularly important to be cautious when combining them with other antihypertensive medications, as this can lead to excessive lowering of blood pressure. Additionally, certain medications for asthma or chronic obstructive pulmonary disease (COPD), such as non-selective beta-agonists, should be avoided, as they can counteract the effects of beta-blockers. Antihistamines, particularly first-generation ones that have sedative effects, may also interact with beta-blockers, leading to increased drowsiness or dizziness.

It is advisable to consult your healthcare provider about any other medications you are taking, including antihistamines, to ensure they are safe to use in conjunction with Concor. Your doctor can provide personalized advice based on your overall health status and medication regimen.

In summary, while your use of Concor may seem concerning given the indication for more severe heart failure, it is likely being used to manage your symptoms related to mitral valve prolapse and autonomic dysfunction. Regular monitoring and open communication with your healthcare provider are essential to ensure safe and effective management of your condition. If you have any concerns about your medications or symptoms, do not hesitate to reach out to your healthcare provider for further evaluation and guidance.

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