Can Cloud Mushroom Polysaccharides Help Chemotherapy-Induced Neuropathy?

"Cloud mushroom polysaccharides"

Hello Dr.
Chen, I would like to ask you about something.
I found some medical articles online stating that "peripheral neuropathy after chemotherapy can be significantly improved by simultaneously using Ganoderma lucidum polysaccharides." What is your opinion on this? Additionally, if it can indeed be effective, would it still be possible to improve the condition after experiencing numbness in the hands and feet for 2-3 years by taking Ganoderma lucidum polysaccharides? Thank you.

Xiao Fen Zi, 30~39 year old female. Ask Date: 2015/10/15

Dr. Chen Sirong reply Oncology

Xiao Fenzi / 38 years old / Female
You may have seen the reports: According to clinical trials, combining chemotherapy with the licensed drug polysaccharide from Ganoderma lucidum to modulate immunity can enhance the efficacy of chemotherapy and significantly improve symptoms of peripheral neuropathy.
Currently, it is covered by health insurance for gastric cancer patients, which is indeed a blessing for many patients.
1.
However, if it can effectively improve symptoms, not all medications work for everyone; some may find it effective while others may not.
2.
If you have been experiencing numbness in your hands and feet for 2-3 years, can taking Ganoderma polysaccharide still lead to improvement? If you belong to the group that responds well, but did not take it initially, starting now may still be beneficial.
If your financial situation allows, you can try it, but it is essential to adhere to the recommended dosage and usage guidelines for a period of time to determine its effectiveness for you.
Taoyuan Hospital, Dr.
Chen Si-Rong

Reply Date: 2015/10/15

More Info

Cloud mushroom polysaccharides, particularly those derived from the species *Trametes versicolor* (commonly known as cloud mushroom or turkey tail), have garnered attention for their potential health benefits, including their use in supporting immune function and possibly alleviating some side effects of chemotherapy. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often debilitating side effect of certain cancer treatments, characterized by symptoms such as numbness, tingling, and pain in the hands and feet.

Research into the effects of cloud mushroom polysaccharides on CIPN is still in its early stages. Some studies suggest that these polysaccharides may have neuroprotective properties, potentially helping to mitigate nerve damage caused by chemotherapy agents. The proposed mechanisms include their ability to enhance antioxidant defenses, reduce inflammation, and support nerve regeneration. However, it is essential to note that while there is some promising evidence, more rigorous clinical trials are needed to establish definitive efficacy and safety for this specific use.

Regarding your situation, where you have been experiencing peripheral neuropathy for 2-3 years, it is crucial to approach the use of any supplement, including cloud mushroom polysaccharides, with realistic expectations. While some individuals may experience improvements in their symptoms, the extent of recovery can vary significantly based on several factors, including the duration and severity of the neuropathy, the specific chemotherapy agents used, and individual health conditions.

If you are considering incorporating cloud mushroom polysaccharides into your regimen, it is advisable to consult with your healthcare provider first. They can provide personalized guidance based on your medical history and current treatment plan. Additionally, they may recommend other supportive therapies that could complement the use of polysaccharides, such as physical therapy, pain management strategies, or other medications specifically aimed at alleviating neuropathic pain.

In summary, while cloud mushroom polysaccharides may offer some potential benefits for individuals suffering from chemotherapy-induced peripheral neuropathy, more research is needed to confirm their effectiveness. If you decide to try them, do so under the supervision of a healthcare professional who can monitor your progress and adjust your treatment plan as necessary.

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