Struggling to Conceive: Irregular Periods and Fertility Issues - Obstetrics and Gynecology

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Inability to conceive?


Hello, doctor.
I am married and have not used contraception for nine months without becoming pregnant.
Additionally, I have not had my period for four months, but pregnancy tests confirm that I am not pregnant.
My menstrual cycle has typically been longer, around 35-40 days, but I have never missed my period for four months.
It is inconvenient for me to seek medical care abroad, and I have already seen my family doctor twice.
Blood tests confirmed that my liver and kidney functions are normal, and there are no thyroid issues.
The doctor agreed to refer me to a gynecologist, but the ultrasound appointment is not available until January next year.
My BMI is 16.5, and I have consistently been underweight without significant fluctuations.
I first went to a general laboratory to check related values: AMH 77.8 pmol/L, which is much higher than the normal range; FSH 3.7 IU/L; LH 18.0 IU/L; prolactin 344 mIU/L; and 17β-estradiol 754 pmol/L.
These tests were not done on the third day of my menstrual cycle (since I have not had a period), and the blood draw was 140 days after my last menstrual period.
What should I do to become pregnant? Thank you!

Niming, 30~39 year old female. Ask Date: 2015/11/18

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, your blood test results are abnormal, indicating that you may not have ovulated, and your prolactin levels are very high.
There is a concern about the possibility of a tumor in the brain affecting pregnancy.
It is recommended that you see a gynecologist for further evaluation.
Wishing you good health.

Reply Date: 2015/11/18

More Info


Struggling to conceive can be a challenging and emotional journey, especially when faced with irregular periods and other fertility issues. Based on the information you've provided, it seems that you have not had a menstrual period for four months, and despite negative pregnancy tests, you are eager to understand your situation better and explore your options for conception.

Firstly, it's important to recognize that irregular menstrual cycles can significantly impact fertility. A typical menstrual cycle ranges from 21 to 35 days, with an average of 28 days. When cycles become irregular or absent, as in your case, it can indicate underlying hormonal imbalances or other health issues that may affect ovulation and, consequently, your ability to conceive.

Your reported hormone levels provide some insights into your reproductive health. The elevated Anti-Müllerian Hormone (AMH) level suggests that you may have a higher ovarian reserve, which is generally a positive sign for fertility. However, the elevated Luteinizing Hormone (LH) level, combined with a relatively low Follicle-Stimulating Hormone (FSH) level, may indicate a condition known as Polycystic Ovary Syndrome (PCOS), which is characterized by hormonal imbalances that can lead to irregular periods and difficulty conceiving. Prolactin levels should also be monitored, as elevated prolactin can interfere with ovulation.

Given your low Body Mass Index (BMI) of 16.5, it's essential to consider the impact of body weight on fertility. Being underweight can disrupt hormonal balance and lead to irregular ovulation or anovulation (lack of ovulation), which can hinder your chances of conceiving. It may be beneficial to work with a healthcare provider or a nutritionist to develop a plan to achieve a healthier weight, which could improve your menstrual regularity and overall reproductive health.

While waiting for your ultrasound appointment, there are several steps you can take to enhance your chances of conception:
1. Track Your Cycle: Even though you haven't had a period in four months, try to monitor any signs of ovulation, such as changes in cervical mucus or basal body temperature. This can help you identify any potential ovulation patterns.

2. Healthy Lifestyle: Focus on maintaining a balanced diet rich in nutrients, engaging in regular physical activity, and managing stress levels. These factors can significantly impact hormonal balance and overall reproductive health.

3. Consult a Specialist: Since your family doctor has already agreed to refer you to a gynecologist, it’s crucial to follow through with that referral. A specialist can provide a more comprehensive evaluation, including potential imaging studies and further hormonal assessments.

4. Consider Fertility Treatments: Depending on the findings from your ultrasound and further evaluations, your healthcare provider may discuss options such as ovulation induction medications or assisted reproductive technologies if necessary.

5. Support and Counseling: The emotional toll of struggling to conceive can be significant. Consider seeking support from counseling or support groups for individuals facing similar challenges.

In summary, while irregular periods can complicate conception, understanding the underlying causes and addressing them through lifestyle changes, medical evaluations, and potential treatments can improve your chances of becoming pregnant. It’s essential to work closely with healthcare professionals who can guide you through this process and provide personalized recommendations based on your specific situation.

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