Does Eating or Drinking Before Taking Cialis Affect Its Effectiveness? - Pharmacology

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Issues with Cialis?


I have a sexual dysfunction, and my doctor prescribed me 5 mg of Cialis to take half a pill before bedtime.
I would like to know if eating or drinking before taking this medication will affect its efficacy.

Liu Zai, 30~39 year old female. Ask Date: 2015/11/20

Dr. Liao Huiling reply Pharmacology


According to current literature, there is no confirmed food that reduces the efficacy of sildenafil.
However, grapefruit juice may affect the metabolism of this medication, potentially increasing the severity of side effects, so it should be used with caution.

Reply Date: 2015/11/20

More Info


Cialis, known generically as tadalafil, is a medication commonly prescribed for erectile dysfunction (ED). When considering its effectiveness, it's essential to understand how food and drink can interact with this medication. Based on the information gathered from various sources, including medical literature and expert opinions, we can clarify the impact of eating or drinking before taking Cialis.

Firstly, it is important to note that Cialis can be taken with or without food. Unlike some other medications for ED, such as Viagra (sildenafil), which may have reduced effectiveness when taken with a high-fat meal, Cialis does not have this limitation. Therefore, consuming food before taking Cialis should not significantly affect its efficacy. This means that if you take Cialis after a meal, it should still work effectively.

However, there are specific considerations regarding certain beverages, particularly grapefruit juice. Grapefruit juice is known to interact with various medications, including some used for erectile dysfunction. It can inhibit the enzyme CYP3A4 in the liver, which is responsible for metabolizing tadalafil. This inhibition can lead to increased levels of the drug in the bloodstream, potentially heightening the risk of side effects. Therefore, it is advisable to avoid grapefruit juice while taking Cialis to ensure that you do not experience any adverse effects or an unexpected increase in the medication's potency.

Regarding other acidic beverages, such as sodas or citrus juices (excluding grapefruit), there is no substantial evidence indicating that they would negatively impact the effectiveness of Cialis. However, it is generally recommended to take medications with water to ensure proper absorption and to avoid any potential interactions with other ingredients in flavored drinks.

In terms of timing, if you are prescribed to take Cialis at bedtime, it is acceptable to have a light meal or drink before taking the medication. Just be cautious with grapefruit juice, as mentioned earlier. If you have any concerns about specific foods or drinks, it is always best to consult your healthcare provider for personalized advice.

In summary, taking Cialis with food does not significantly affect its effectiveness, but it is wise to avoid grapefruit juice due to its potential interaction with the medication. For optimal results, taking Cialis with water and avoiding grapefruit juice is recommended. If you have further questions or concerns about your treatment plan, discussing them with your healthcare provider is crucial to ensure safe and effective management of your erectile dysfunction.

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