Warts Treatment: Persistent Blisters After Cryotherapy - Dermatology

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The warts have been treated for a long time?


Hello doctor, I have started treatment for warts and have undergone 6 to 7 sessions of cryotherapy.
I have also been applying medication and using adhesive bandages.
The warts are located on my toes, and they have recurred after the cryotherapy.
After the treatment, I developed blisters, which have persisted for several weeks without healing.
Is this normal? Recently, the blisters not only haven't healed but have also grown larger.
Could this be due to friction from walking? In previous treatments, the skin would peel off immediately, but this time it has taken much longer.

Ren, 20~29 year old female. Ask Date: 2015/11/21

Dr. Li Yufen reply Dermatology


Hello: It is possible to develop blisters after cryotherapy, but they typically do not persist for several weeks.
It is recommended that you return for a follow-up appointment so that a dermatologist can assist you with the blister issue.
Thank you!

Reply Date: 2015/11/21

More Info


Warts, particularly those located on the feet (commonly known as plantar warts), can be quite stubborn and may require multiple treatments to effectively eliminate them. Cryotherapy, which involves freezing the wart with liquid nitrogen, is a common and effective method for wart removal. However, it is not uncommon for patients to experience persistent blisters or fluid-filled lesions following cryotherapy, especially after multiple sessions.

In your case, the presence of blisters that have persisted for several weeks after cryotherapy is not entirely unusual. After the freezing process, the skin may react by forming blisters as part of the healing process. These blisters can be filled with clear fluid and may take time to resolve. However, if the blisters are increasing in size or not showing signs of improvement, it may indicate a few potential issues.

1. Infection: One concern with persistent blisters is the possibility of infection. If the blister becomes red, warm, or increasingly painful, or if there is pus, it may be infected and would require medical evaluation and possibly antibiotic treatment.

2. Irritation: As you mentioned, friction from walking or wearing shoes can exacerbate the situation. If the area is being irritated, it can lead to increased blistering and prolonged healing. It is advisable to wear comfortable shoes that do not rub against the affected area and to avoid activities that may cause further irritation.

3. Treatment Response: Each individual's skin responds differently to treatments. Some may experience quicker healing and resolution of blisters, while others may have a delayed response. The fact that previous treatments resulted in quicker peeling and healing does not necessarily predict the outcome of subsequent treatments.

4. Wart Recurrence: It's also important to consider that the wart may not have been completely eradicated, leading to continued irritation and blistering. Warts can be resilient, and sometimes additional treatments or alternative methods may be necessary.

In terms of management, here are some recommendations:
- Avoid Popping the Blisters: It is generally advised not to pop or drain blisters, as this can increase the risk of infection. If the blister is large and painful, consult with a healthcare provider for appropriate management.

- Keep the Area Clean and Dry: Maintain good hygiene and keep the area dry to promote healing. You can cover the blister with a sterile bandage to protect it from further irritation.

- Consult Your Healthcare Provider: If the blisters do not improve, continue to grow, or if you notice any signs of infection, it is crucial to follow up with your healthcare provider. They may recommend further evaluation or alternative treatments, such as topical medications, laser therapy, or even surgical removal if necessary.

- Consider Alternative Treatments: If cryotherapy is not yielding the desired results, discuss with your healthcare provider about other treatment options available for warts, such as salicylic acid, laser therapy, or immunotherapy.

In conclusion, while persistent blisters after cryotherapy can be a normal part of the healing process, they should be monitored closely. If there are any concerns regarding infection or if the blisters do not resolve, seeking medical advice is essential. Your healthcare provider can offer tailored recommendations based on your specific situation and ensure that you receive the most effective treatment for your warts.

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