Cervical Smear Results: HPV Negative and Normal Findings - Obstetrics and Gynecology

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Issues related to Pap smears?


Hello, doctor.
I had an abnormal Pap smear around 1999, which was diagnosed as CIN2.
I underwent a cone biopsy, and the margins and endocervical cells were clear.
At that time, I also tested positive for HPV type 52.
Since then, I have been monitored every six months, and all results have been normal.
During this period, I gave birth to two children.
Because of the cone biopsy, I had a cervical cerclage during my pregnancies to prevent preterm labor.
Recently, I realized it had been a while since my last HPV test, so I underwent a traditional Pap smear and HPV testing.
The results came back normal and negative.
Given that my HPV is negative and my Pap smear is normal, can I feel more reassured and continue with regular Pap smear follow-ups? Does this mean my risk of developing cervical cancer is lower now? Thank you.

Niming, 30~39 year old female. Ask Date: 2015/11/25

Dr. Lü Lizheng reply Obstetrics and Gynecology


The results of the Pap smear and HPV test are normal and negative, which significantly reduces the risk of cervical cancer.
Sincerely, Dr.
Li-Cheng Lu, Taoyuan Hospital.

Reply Date: 2015/11/25

More Info


Understanding your cervical smear results, especially in the context of previous abnormalities and HPV infections, is crucial for your ongoing health management. Based on your history of CIN2 and subsequent treatments, it is encouraging to hear that your recent Pap smear and HPV test results have come back normal and negative, respectively.
1. HPV Negative and Normal Pap Smear: A negative HPV test indicates that there is no detectable high-risk HPV present in your system at this time. This is a positive sign, as high-risk HPV types are known to be the primary cause of cervical cancer. A normal Pap smear result means that there are no abnormal cells detected in the cervical tissue. Together, these results significantly reduce your risk of developing cervical cancer in the near future.
2. Follow-Up and Monitoring: Given your history of CIN2 and the treatments you have undergone, it is essential to continue regular monitoring. The current guidelines suggest that women with a history of cervical precancer should have Pap smears and HPV tests at regular intervals, typically every 3 to 5 years, depending on your age and health history. Since your recent results are normal, you can generally feel more at ease, but it is still important to adhere to your follow-up schedule.

3. Risk of Cervical Cancer: While your recent results are reassuring, it is important to remember that the risk of cervical cancer does not disappear entirely. The fact that you had CIN2 in the past means that you have a slightly elevated risk compared to someone who has never had cervical abnormalities. However, with consistent monitoring and a healthy lifestyle, this risk can be managed effectively.
4. Factors Influencing Cervical Health: Your concern about factors such as fatigue and a weakened immune system is valid. Chronic stress and a compromised immune system can affect your body’s ability to fight off infections, including HPV. Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and stress management, can help support your immune system.
5. Future Considerations: It is also worth noting that if you experience any unusual symptoms, such as abnormal bleeding or pelvic pain, you should consult your healthcare provider promptly. Additionally, discussing the HPV vaccine with your doctor may be beneficial, as it can protect against the most common high-risk HPV types, further reducing your risk of cervical cancer.

In summary, your recent normal Pap smear and negative HPV test are excellent news and suggest a lower risk of cervical cancer moving forward. However, continued vigilance through regular screenings is essential, especially given your medical history. Always feel empowered to discuss any concerns with your healthcare provider, as they can offer personalized advice and support based on your unique health profile.

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