Does Favism Disappear with Age? the Condition - Internal Medicine

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Favism, also known as G6PD deficiency or glucose-6-phosphate dehydrogenase deficiency, is a genetic condition that affects the body's ability to process certain substances, particularly those found in fava beans and some other foods and medications. This condition is caused by a deficiency in the G6PD enzyme, which plays a crucial role in protecting red blood cells from oxidative damage.
To address your question directly: Favism does not disappear with age. G6PD deficiency is an inherited condition, meaning that individuals are born with it, and it persists throughout their lives. The severity of symptoms can vary among individuals, and while some may experience more severe reactions to triggers (like fava beans, infections, or certain medications), the underlying deficiency remains constant.

As individuals with G6PD deficiency age, they may experience changes in their health that could affect how their body responds to oxidative stress. For example, older adults may have a higher risk of developing other health conditions that could complicate their management of G6PD deficiency. However, the fundamental genetic predisposition does not change.

Management of G6PD deficiency primarily involves avoiding known triggers. For individuals with this condition, it is crucial to:
1. Avoid Fava Beans: As the name "favism" suggests, fava beans can trigger hemolytic anemia in individuals with G6PD deficiency. It is essential to avoid these beans entirely.

2. Be Cautious with Medications: Certain medications, including some antibiotics (like sulfonamides), antimalarials, and non-steroidal anti-inflammatory drugs (NSAIDs), can also trigger hemolysis. Patients should always inform healthcare providers of their G6PD status before starting any new medication.

3. Monitor for Infections: Infections can increase oxidative stress on red blood cells, leading to hemolysis. Prompt treatment of infections is vital for individuals with G6PD deficiency.

4. Regular Check-ups: Regular medical check-ups can help monitor overall health and manage any complications that may arise from G6PD deficiency or other age-related health issues.

5. Educate Family and Friends: It is beneficial for those close to individuals with G6PD deficiency to understand the condition, its triggers, and how to assist in avoiding potential risks.

In conclusion, while G6PD deficiency does not disappear with age, individuals can lead healthy lives by managing their condition effectively. Awareness and education about the condition are key to preventing complications. If you or someone you know has G6PD deficiency, it is advisable to work closely with healthcare providers to develop a personalized management plan that considers both the condition and any other health issues that may arise with aging.