Oral White Bumps: HPV or HSV Concerns? - Otolaryngology

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White lesions in the oral cavity?


Hello doctor, I discovered HPV in my anal area last December and after six months of treatment, I have fully recovered.
However, a month ago, I found a small white spot in my mouth, about 0.2 cm in size, which is painless and resembles a blister.
I became too anxious and picked at it, and it came off easily.
Today, I noticed a similar small blister in another area of my mouth.
I went to see a doctor, who advised me to observe it for a while and mentioned that it could possibly be HSV.
I would like to ask if this could be HPV, as I have read a lot of information stating that HPV lesions bleed when picked at, but when I picked it off for the first time, there was no bleeding.
Also, if it is HSV, can it be transmitted to other areas through hand contact? Thank you, doctor.

Xiao An, 20~29 year old female. Ask Date: 2015/12/02

Dr. Zheng Jueyi reply Otolaryngology


Hello, if blisters continue to appear, you should visit the hospital's infectious disease department for examination.
HSV usually resides in the nerve ganglia and can reactivate when immunity is low.
It is indeed advisable to avoid popping the blisters with your hands to prevent infection in other areas.
Wishing you safety and health.
Sincerely, Dr.
Cheng Jue-Yi, Director of the Department of Otolaryngology, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2015/12/02

More Info


When it comes to oral white bumps, distinguishing between HPV (Human Papillomavirus) and HSV (Herpes Simplex Virus) can be challenging, especially given your recent medical history. Based on your description, it seems you have developed small white bumps in your mouth that resemble blisters, which you noted are painless and easily removable.
Firstly, let's clarify the characteristics of both HPV and HSV. HPV is primarily known for causing warts, including genital warts, and can also lead to lesions in the oral cavity, particularly in cases of oral HPV infection. These lesions can sometimes appear as white bumps or patches. However, HPV lesions are typically more persistent and may not be easily removed without causing bleeding or discomfort. The fact that you did not experience bleeding when you removed the bump could suggest that it may not be HPV-related.

On the other hand, HSV, particularly HSV-1, is commonly associated with oral herpes, which can manifest as cold sores or blisters around the mouth. HSV-2 is more commonly linked to genital infections but can also infect the oral area through oral-genital contact. The appearance of a blister-like bump that is painless and easily removable aligns more closely with HSV, especially if you have a history of cold sores or have engaged in oral sexual activities.

Regarding your concern about the potential for HSV to spread to other areas of your body, it is indeed possible. If the virus is present on your hands and you touch another area of your body, such as your eyes or genitals, there is a risk of autoinoculation, which is the process of transferring the virus from one part of your body to another. This is why it is generally advised to avoid touching any lesions and to wash your hands thoroughly after any contact with them.

In terms of your specific situation, since you have already consulted a physician who suggested observation, it is essential to follow their advice. If the bumps persist, change in appearance, or if you develop additional symptoms (such as pain, itching, or swelling), it would be prudent to seek further evaluation, possibly from a specialist in infectious diseases or dermatology. They may recommend a viral culture or PCR test to definitively identify the presence of HSV or HPV.

Additionally, it is important to maintain good oral hygiene and avoid any irritants that could exacerbate the condition. If you have a history of HSV, consider discussing with your healthcare provider the possibility of antiviral medications, which can help manage outbreaks and reduce transmission risk.

In summary, while both HPV and HSV can cause oral lesions, the characteristics of your bumps and your medical history suggest a higher likelihood of HSV involvement. Monitoring the situation and consulting with healthcare professionals for further evaluation and management is the best course of action. Always prioritize hygiene and avoid manipulating any lesions to reduce the risk of spreading the virus.

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