Delayed Menstruation: Causes and Cancer Concerns - Obstetrics and Gynecology

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Delayed menstruation?


Hello doctor, my menstrual cycle has always been quite regular, occurring every 28 to 35 days.
However, my last period was late; it started on November 18, making the cycle 36 days long.
Since then, I haven't had my period.
I had sexual intercourse on December 10 with full protection.
On December 24, I visited a gynecologist, took a pregnancy test, and it was negative.
The doctor then performed an ultrasound and mentioned that my ovaries appeared to have ovulated, and my endometrial lining was quite thick at 15.7 mm.
She prescribed me a 5-day course of progesterone to induce my period and advised me to return for a follow-up if my period comes within 7 days.
Lastly, she expressed concern about cancer and questioned why my period was so late, which made me very anxious.
I would like to know what factors could cause my period to be late for these two months and what the connection to cancer might be.
I'm feeling quite scared.

Wu, 20~29 year old female. Ask Date: 2015/12/26

Dr. Lin Wenbin reply Obstetrics and Gynecology


Medical examinations take time, and often results cannot be obtained in just one day.
Please cooperate with your physician for follow-up visits.

Reply Date: 2015/12/26

More Info


Delayed menstruation can be a source of concern for many women, especially when accompanied by other symptoms or when there is a fear of underlying health issues, including cancer. It’s important to understand that there are numerous factors that can contribute to changes in menstrual cycles, and while some may be benign, others may warrant further investigation.

Firstly, a normal menstrual cycle typically ranges from 21 to 35 days, and variations can occur due to a variety of reasons. Stress, significant weight changes, hormonal imbalances, and lifestyle factors such as diet and exercise can all influence menstrual regularity. For instance, high levels of stress can lead to hormonal fluctuations that may delay ovulation, resulting in a longer cycle. Similarly, significant weight loss or gain can affect the body’s hormonal balance, potentially leading to missed or delayed periods.

In your case, you mentioned that your last menstrual period was on November 18, and since then, you have experienced a delay. You also noted that you had a sexual encounter on December 10, but pregnancy tests returned negative, which is reassuring. The ultrasound indicated that your ovaries appeared to have ovulated, and the endometrial lining was thick, which is consistent with the hormonal changes that occur after ovulation.

The prescription of progesterone (luteal hormone) by your doctor is a common approach to induce menstruation when there is a delay. Progesterone helps to prepare the uterine lining for a potential pregnancy, and if pregnancy does not occur, it triggers menstruation. The concern your doctor expressed regarding cancer is likely related to the thickened endometrial lining (15.7 mm), which can sometimes be a sign of abnormal hormonal stimulation or other underlying conditions, including hyperplasia or, in rare cases, endometrial cancer.

While it’s understandable to feel anxious about the possibility of cancer, it’s essential to recognize that a thickened endometrial lining can have many benign causes, such as hormonal imbalances, especially if you are still in your reproductive years. Conditions like polycystic ovary syndrome (PCOS) or simple hormonal fluctuations can lead to similar findings without malignancy.

However, if there are persistent changes in your menstrual cycle, especially if accompanied by other symptoms such as abnormal bleeding, pelvic pain, or significant weight changes, it is crucial to follow up with your healthcare provider. They may recommend further evaluation, such as a biopsy of the endometrial lining, to rule out any serious conditions.

In summary, while delayed menstruation can be concerning, it is often due to non-cancerous factors. Maintaining open communication with your healthcare provider and following their recommendations for monitoring and further evaluation is the best course of action. If you continue to experience anxiety about your health, consider discussing your concerns with a mental health professional, as managing stress and anxiety can also positively impact your overall health and menstrual regularity.

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