Cancer-Related Fatigue: Symptoms, Causes, and Concerns - Oncology

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Cancer-related fatigue


Hello Doctor, I have recently read about cancer-related fatigue, which includes symptoms such as "physical and mental exhaustion, fatigue, lethargy, tiredness, feeling drained, listlessness, weakness in the limbs, forgetfulness, difficulty concentrating, emotional numbness, decreased willingness to participate in social activities, inability to enjoy life, and lack of a sense of accomplishment in work...
In fact, 'fatigue' is more distressing than hair loss, vomiting, or pain." This level of exhaustion resonates with my condition, and I also experience hypersomnia; no matter how much I sleep, I still feel tired.
However, my current internal medicine examinations are normal, and there are no signs of tumors.
My sleep apnea is mild after surgery, with an average low oxygen saturation of 93% during sleep.
I do not experience insomnia, have a good appetite, and my psychological stress and anxiety levels are low.
A doctor once suspected that my condition might be due to a tumor, but the abdominal CT scan was normal.
I would like to know if cancer-related fatigue (CRF) only occurs during chemotherapy for cancer patients, or can it also occur in the pre-treatment phase of cancer? Has anyone been diagnosed with cancer as a result of experiencing this fatigue?

Niming, 40~49 year old female. Ask Date: 2015/12/29

Dr. Lai Yicheng reply Oncology


Hello, Sir: Fatigue is a common symptom in various chronic diseases and is characterized as a subjective feeling or objective decline in physical capacity.
Out of respect for cancer patients, cancer-related fatigue (CRF) has traditionally been defined as a self-perceived symptom that essentially refers to a subjective experience of fatigue or lack of energy, which can vary in severity, frequency, and duration in clinical settings.
Despite extensive research over the past decade, there is still a lack of a comprehensive theory regarding the causes of fatigue.
Numerous factors have been discussed, including medical conditions, biochemical and psychological factors, with emotional disturbances being particularly significant.
If there are sleep-related issues, it is advisable to seek assistance from a neurologist or a specialist in sleep disorders.
Changhua Hospital cares about you.
Sincerely, Director Lai, Department of Radiation Oncology.

Reply Date: 2015/12/29

More Info


Cancer-related fatigue (CRF) is a complex and multifaceted condition that extends beyond the physical exhaustion commonly associated with cancer treatment. It is characterized by a profound sense of tiredness that is not alleviated by rest and can significantly impact a person's quality of life. Your description of symptoms, including physical and mental fatigue, lack of energy, and emotional numbness, aligns closely with the experiences of many individuals dealing with CRF.

CRF can occur at any stage of cancer, not just during treatment such as chemotherapy. It can manifest even in the early stages of the disease, sometimes before a diagnosis is made. This fatigue is not merely a result of the cancer itself but can also be influenced by various factors, including psychological stress, sleep disturbances, and metabolic changes associated with the disease. In some cases, individuals may experience CRF as a symptom that prompts further investigation, leading to the discovery of an underlying malignancy.

The symptoms you describe—excessive daytime sleepiness, persistent fatigue despite adequate sleep, and cognitive difficulties—are indeed concerning. While your recent medical evaluations have returned normal results, it is essential to recognize that CRF can exist independently of detectable tumors or other obvious medical conditions. The interplay of physical, psychological, and social factors can contribute to the development of fatigue, making it a challenging symptom to address.

In your case, the fact that you have undergone thorough medical evaluations, including CT scans, and have not been diagnosed with cancer is reassuring. However, it is crucial to continue monitoring your symptoms and to communicate openly with your healthcare providers about your experiences. If your fatigue persists or worsens, further evaluations may be warranted to explore other potential causes, such as sleep disorders, hormonal imbalances, or chronic fatigue syndrome.

It is also worth noting that CRF can be exacerbated by lifestyle factors, including poor sleep hygiene, lack of physical activity, and inadequate nutrition. Engaging in regular physical activity, maintaining a balanced diet, and practicing good sleep habits can help mitigate some of the fatigue you are experiencing. Additionally, psychological support, whether through counseling or support groups, can be beneficial in managing the emotional aspects of fatigue.

In conclusion, cancer-related fatigue is a significant concern that can affect individuals at various stages of their cancer journey. It is not limited to those undergoing treatment and can be a symptom that leads to further investigation. If you continue to experience debilitating fatigue, it is essential to work closely with your healthcare team to identify potential underlying causes and develop a comprehensive management plan tailored to your needs. Remember, you are not alone in this experience, and support is available to help you navigate these challenges.

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