Does Taking Emergency Contraceptive Pills Multiple Times Affect Fertility? - Pharmacology

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Third time taking emergency contraceptive pills?


Doctor, will taking the emergency contraceptive pill for the third time cause infertility? The intervals have been more than a month apart! I didn't experience significant side effects during the first two times, just that my period came a week early once and a week late another time.
I mainly want to ask if this could lead to infertility?

Xi Li, 10~19 year old female. Ask Date: 2016/01/05

Dr. Yang Ruifa reply Pharmacology


Regarding your inquiry, here is the response:
1.
Emergency contraceptive pills contain high doses of progestin and have significant side effects.
In fact, emergency contraceptive pills are not foolproof; their efficacy can reach 95% if taken within 24 hours, but effectiveness declines significantly after that, dropping to 58% by the third day.
If taken during ovulation, there is still a possibility of pregnancy.
Additionally, emergency contraceptive pills contain 8 to 10 times higher doses of progestin and estrogen compared to regular contraceptives.
Such high doses can lead to side effects including nausea, vomiting, dizziness, fatigue, abdominal pain, and breast tenderness.
Using them more than once within a month can cause menstrual irregularities, and in some cases, menstruation may be delayed.
2.
Will the use of emergency contraceptive pills cause infertility? The primary mechanism of action of emergency contraceptive pills is to inhibit or delay ovulation.
If used frequently over a long period, clinical observations indicate that they can lead to menstrual irregularities.
However, consultations with obstetricians and gynecologists suggest that they do not cause infertility.

Reply Date: 2016/01/05

More Info


Taking emergency contraceptive pills (ECPs) multiple times does raise concerns for many women regarding potential impacts on fertility. However, the current medical consensus is that using ECPs, even multiple times, does not have a long-term effect on a woman's fertility.

Emergency contraceptive pills, such as those containing levonorgestrel (Plan B) or ulipristal acetate (ella), are designed to prevent pregnancy after unprotected intercourse or contraceptive failure. They work primarily by delaying ovulation, preventing fertilization, or inhibiting implantation of a fertilized egg. Importantly, these pills are not intended for regular contraceptive use and should only be used in emergencies.

Regarding your specific question about whether taking ECPs multiple times can lead to infertility, research indicates that there is no evidence to suggest that repeated use of ECPs affects a woman's ability to conceive in the future. The hormonal doses in ECPs are designed to act quickly and do not have a cumulative effect that would impair fertility. The body typically returns to its normal ovulatory cycle shortly after taking the pills, although some women may experience temporary changes in their menstrual cycle, such as earlier or later periods, as you have noted.

It's essential to understand that while ECPs are safe and effective for preventing pregnancy, they are not a substitute for regular contraceptive methods. Frequent reliance on emergency contraception may indicate a need for a more reliable contraceptive strategy. If you find yourself needing ECPs often, it may be beneficial to consult with a healthcare provider to discuss long-term contraceptive options that suit your lifestyle and health needs.

In terms of side effects, it is common for women to experience some changes in their menstrual cycle after taking ECPs, such as spotting, changes in flow, or timing of their periods. These effects are usually temporary and resolve within one or two cycles. If you experience significant or prolonged changes in your menstrual cycle or any concerning symptoms, it is advisable to seek medical advice.

In summary, taking emergency contraceptive pills multiple times does not cause infertility. However, if you have concerns about your reproductive health or contraceptive methods, it is always best to consult with a healthcare professional who can provide personalized advice and support.

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