Post-Surgery Treatment Options for Breast Cancer - Oncology

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Post-treatment for breast cancer?


Your mother is currently sixty years old and underwent a left mastectomy on December 21, 2015.
The tumor measured 0.7 cm with no lymph node metastasis, and testing revealed HER2+++ which is considered positive.
The physician has recommended chemotherapy along with hormone therapy.
You are inquiring whether chemotherapy is absolutely necessary.

While chemotherapy is often recommended for HER2-positive breast cancer to reduce the risk of recurrence, the decision ultimately depends on various factors including the specific characteristics of the tumor, overall health, and personal preferences.
Hormonal therapy alone may be an option, especially given the hormone receptor status of 10% for estrogen and 40% for progesterone.

However, it's important to discuss all treatment options, including the potential benefits and risks of chemotherapy versus hormone therapy, with the oncologist.
Targeted therapy could also be considered, but as you mentioned, it may not be covered by insurance.
It is crucial to have a thorough discussion with the healthcare provider to make an informed decision that aligns with your mother's health goals and circumstances.

han, 30~39 year old female. Ask Date: 2016/01/05

Dr. Lai Yicheng reply Oncology


Ms.
Han: 1.
Your mother has a left breast cancer tumor measuring 0.7 cm, with no lymph node metastasis.
Her2 is 3+ (positive), estrogen receptor positive (+, 10%), and progesterone receptor positive (+, 40%).
She underwent a left mastectomy on December 21, 2015.
2.
According to the NCCN treatment guidelines, your mother must undergo hormone therapy.
However, the decision regarding adjuvant chemotherapy falls into a gray area; it can be done or not done.
Please discuss this with her attending physician.
As for targeted therapy (which does not meet the insurance reimbursement criteria and would be out-of-pocket), it depends on your financial situation.
If financially feasible, I still recommend considering targeted therapy.
Changhua Hospital is concerned about you.
Sincerely, Dr.
Lai Yi-Cheng, Department of Radiation Oncology.

Reply Date: 2016/01/05

More Info


When it comes to post-surgery treatment options for breast cancer, particularly in the case of your mother who is 60 years old and has undergone a total mastectomy, there are several important factors to consider. The tumor size of 0.7 cm and the absence of lymph node metastasis are positive indicators, but the HER2+++ status indicates that the cancer is HER2 positive, which can influence treatment decisions significantly.

HER2 positive breast cancer is known to be more aggressive than HER2 negative types, and it often requires a more intensive treatment approach. The recommendation for chemotherapy combined with hormone therapy is based on the need to address both the aggressive nature of HER2 positive cancer and the hormone receptor status. In your mother's case, with estrogen receptor (ER) positivity at 10% and progesterone receptor (PR) positivity at 40%, hormone therapy could be beneficial, but it may not be sufficient on its own.

Chemotherapy is often recommended for HER2 positive breast cancer because it can help to reduce the risk of recurrence by targeting any remaining cancer cells after surgery. While it is true that chemotherapy can affect both healthy and cancerous cells, the goal is to maximize the destruction of cancer cells while minimizing damage to healthy tissues. The combination of chemotherapy and targeted therapy (like trastuzumab, commonly known as Herceptin) is particularly effective for HER2 positive breast cancer, as it specifically targets the HER2 protein on cancer cells, leading to better outcomes.

If the health insurance does not cover targeted therapy, it is essential to discuss this with the oncologist. They may have alternative options or financial assistance programs that could help manage the costs. It is also important to weigh the risks and benefits of foregoing chemotherapy. While hormone therapy alone may seem appealing, it may not provide the same level of protection against recurrence in HER2 positive cases.

In summary, while it is understandable to have concerns about the side effects of chemotherapy, it is crucial to follow the oncologist's recommendations based on the specific characteristics of the cancer. The treatment plan should be tailored to your mother's individual situation, taking into account her overall health, the specific cancer biology, and her preferences. Engaging in a thorough discussion with her healthcare team about the potential benefits and risks of each treatment option will help in making an informed decision that aligns with her treatment goals.

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