Thyroid Nodules: Causes, Concerns, and Management - Internal Medicine

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Thyroid nodule


Three months ago, during a health check-up, a lump was found in my neck.
I was referred to a physician at Tri-Service General Hospital who diagnosed it as a thyroid goiter.
The lump feels somewhat soft and is not painful.
No further ultrasound or biopsy was performed, and no medication was prescribed.
However, it has not decreased in size to this day.
Can the possibility of a tumor be ruled out? If it is simply a case of thyroid inflammation, can the lump persist for several months without resolution? Is it related to high endocrine stress? Thank you for your clarification.

Jiaqi, 40~49 year old female. Ask Date: 2016/02/03

Dr. Gao Jiankai reply Internal Medicine


Dear Mr.
Chia-Chi,
Thank you for your email, and I apologize for the delayed response due to the New Year holiday.
It is quite challenging to assess whether a thyroid enlargement is due to inflammation or a tumor solely by palpation.
If necessary, ultrasound-guided sampling is the most definitive method for diagnosis.
The physician will also evaluate thyroid function and related markers to assist in diagnosis and treatment planning.
It may be difficult to expect it to resolve on its own, so I recommend that you consult with an endocrinologist.
As for whether stress can exacerbate thyroid conditions, I believe there is a connection, but the current evidence is not conclusive.
Therefore, attributing thyroid issues entirely to stress remains a topic of debate.
Regardless, I strongly encourage you to see an endocrinologist.
Best regards,
Department of Allergy, Immunology, and Rheumatology, Changhua Hospital, Ministry of Health and Welfare

Reply Date: 2016/02/03

More Info


Understanding thyroid nodules is crucial for anyone who has been diagnosed with a thyroid condition, especially after discovering a lump in the neck. Thyroid nodules are common, and while most are benign, some can be indicative of more serious conditions, including thyroid cancer.
When you mention that you have a soft, non-painful lump in your neck that has not resolved after three months, it is understandable to have concerns about the possibility of a tumor. Thyroid nodules can arise from various causes, including benign conditions like colloid nodules, thyroiditis (inflammation of the thyroid), or more serious conditions like thyroid cancer. The fact that your doctor has diagnosed it as a thyroid nodule and has not recommended immediate intervention suggests that they may not have significant concerns about malignancy at this point.
However, the persistence of the nodule for several months without resolution can be concerning. In cases of thyroiditis, it is possible for inflammation to cause swelling that may last for an extended period. Autoimmune thyroiditis, such as Hashimoto's thyroiditis, can lead to chronic inflammation of the thyroid gland, resulting in nodular enlargement. This condition can indeed be associated with stress, as stress can exacerbate autoimmune conditions and lead to fluctuations in thyroid hormone levels.

To address your concerns about the possibility of a tumor, it is important to consider a few factors. First, the characteristics of the nodule, such as its size, consistency, and whether it is causing any symptoms (like difficulty swallowing or breathing), play a significant role in determining the next steps. If the nodule is soft and non-tender, it is less likely to be cancerous, but this does not completely rule out the possibility.
Typically, if a nodule is larger than 1 cm or shows suspicious features on ultrasound (such as irregular borders or microcalcifications), a fine needle aspiration (FNA) biopsy may be recommended to rule out cancer. If your doctor has not suggested this, it may be because they believe the risk of malignancy is low based on your examination and any imaging studies that may have been performed.

In terms of management, if the nodule is benign and not causing any symptoms, your doctor may recommend a "watchful waiting" approach, which involves regular monitoring of the nodule with follow-up ultrasounds to assess for any changes in size or characteristics. If the nodule continues to grow or if you develop new symptoms, further evaluation may be warranted.

Regarding your question about whether stress could be related to the persistence of the nodule, while stress can affect thyroid function and exacerbate existing thyroid conditions, it is not typically a direct cause of thyroid nodules. However, managing stress through lifestyle changes, such as regular exercise, a balanced diet, and mindfulness practices, can be beneficial for overall health and may help in managing thyroid-related symptoms.

In conclusion, while the presence of a thyroid nodule can be concerning, many are benign and do not require immediate treatment. Regular follow-up with your healthcare provider, monitoring the nodule, and possibly obtaining further imaging or biopsy if indicated are essential steps in managing your condition. If you have ongoing concerns, it may be worthwhile to seek a second opinion or discuss your situation further with an endocrinologist who specializes in thyroid disorders.

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