Oral Leukoplakia: Causes and Concerns - Dentistry

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Oral leukoplakia


Hello Doctor: I would like to ask about a recent condition my family member is experiencing, where there are white patches in the mouth, accompanied by a persistent dry sensation.
They do not smoke, drink alcohol, or chew betel nut.
What could be the possible causes? Thank you!

Xiao Si, 20~29 year old female. Ask Date: 2016/02/03

Dr. Zeng Guanghui reply Dentistry


The above condition may be an inflammatory response caused by excessive keratinization of the oral epithelium, which is related to emotional stress or lack of sleep.
It is recommended to consult a dentist for further examination.

Reply Date: 2016/02/03

More Info


Oral leukoplakia is a condition characterized by white patches or plaques that develop on the mucous membranes of the mouth. These patches cannot be easily wiped away and can vary in size and shape. Understanding the causes and concerns associated with oral leukoplakia is crucial, especially since it can sometimes indicate underlying health issues.


Causes of Oral Leukoplakia
1. Irritation: Chronic irritation from factors such as rough teeth, ill-fitting dentures, or frequent cheek biting can lead to the development of leukoplakia. This irritation causes the cells in the oral mucosa to proliferate, resulting in the formation of white patches.

2. Tobacco Use: While your family member does not smoke or chew betel nut, it’s important to note that tobacco use is one of the most common causes of leukoplakia. Even secondhand smoke can contribute to the condition.

3. Alcohol Consumption: Similar to tobacco, alcohol can irritate the oral mucosa and lead to leukoplakia. However, in this case, the absence of alcohol consumption is noted.

4. Human Papillomavirus (HPV): Certain strains of HPV have been linked to oral leukoplakia. This virus can cause changes in the cells of the oral cavity, leading to the development of white patches.

5. Immune System Disorders: Conditions that compromise the immune system, such as HIV/AIDS, can increase the risk of developing leukoplakia.

6. Nutritional Deficiencies: Deficiencies in certain vitamins, particularly vitamin B12, folate, and iron, can lead to changes in the oral mucosa, including leukoplakia.

7. Systemic Diseases: Some systemic diseases, such as lichen planus or systemic lupus erythematosus, can manifest in the oral cavity as leukoplakia.


Concerns Associated with Oral Leukoplakia
1. Potential for Malignancy: One of the primary concerns with leukoplakia is its potential to be precancerous. While not all leukoplakia lesions are cancerous, some can develop into oral squamous cell carcinoma. It is essential to monitor these lesions closely and seek medical advice.

2. Diagnosis: A definitive diagnosis often requires a biopsy of the affected tissue. This procedure helps determine whether the leukoplakia is benign or if there are any dysplastic (precancerous) changes present.

3. Symptoms: In addition to the appearance of white patches, individuals may experience discomfort, a burning sensation, or a feeling of dryness in the mouth. These symptoms can significantly affect quality of life, making it difficult to eat or speak comfortably.

4. Psychological Impact: The presence of oral leukoplakia can lead to anxiety and stress, particularly if there is concern about the potential for cancer. It is important to address these psychological aspects alongside the physical symptoms.


Recommendations
Given the symptoms described, it is advisable for your family member to consult with a healthcare professional, preferably an oral surgeon or a dentist specializing in oral pathology. A thorough examination, including a possible biopsy, will help determine the nature of the leukoplakia and whether any treatment is necessary.

In the meantime, maintaining good oral hygiene is crucial. This includes regular brushing and flossing, as well as using an alcohol-free mouthwash to avoid further irritation. Additionally, addressing any potential nutritional deficiencies through diet or supplements may be beneficial.


Conclusion
Oral leukoplakia can arise from various causes, and while it may not always indicate a serious condition, it is essential to take it seriously. Regular dental check-ups and prompt attention to any changes in the oral cavity can help manage the condition effectively and reduce the risk of complications.

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